Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13560521 | 0.86 | ECE1 (0.39) | MMP13KMT2AMEN1SMN1; SMN2KDM4E | |
| SCHEMBL3639291 | 0.84 | MMP13 (0.52) | MMP13KMT2AMEN1CYP2C19SMN1; SMN2 | |
| SCHEMBL3036607 | 0.82 | MMP13 (0.47) | MMP13KMT2AMEN1CYP2C19SMN1; SMN2 | |
| SCHEMBL3637426 | 0.80 | ABCB11 (0.45) | KMT2AMEN1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL13560519 | 0.77 | TSPO (0.38) | MMP13KMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3638010 | 0.75 | CCR2 (0.50) | KMT2AMEN1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL3675353 | 0.72 | KDM4E (0.42) | KMT2AMEN1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL3639124 | 0.72 | SRD5A2 (0.69) | KMT2AMEN1KDM4EALDH1A1NPC1 | |
| SCHEMBL3641237 | 0.72 | ACSS2 (0.38) | KMT2AMEN1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL3634758 | 0.71 | SRD5A2 (0.44) | KMT2AMEN1SMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166856-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154271-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-18 | — | — | WO | disclosed |