Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 5/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL367222 | 0.92 | EGFR (0.41) | EGFRSRCELANEHTR2AHTR2C | |
| SCHEMBL366821 | 0.90 | AGTR1 (0.41) | EGFRSRCKDM4EAGTR1RORC | |
| SCHEMBL365771 | 0.89 | EGFR (0.43) | EGFRSRCKDM4EHTR2AHTR2C | |
| SCHEMBL367256 | 0.89 | EGFR (0.40) | EGFRSRCKDM4EAGTR1ELANE | |
| SCHEMBL365789 | 0.82 | EGFR (0.41) | EGFRSRCKDM4EAGTR1ALDH1A1 | |
| SCHEMBL365273 | 0.82 | PLA2G4A (0.45) | EGFRSRCKDM4ERORC | |
| SCHEMBL366790 | 0.78 | EGFR (0.41) | EGFRSRCKDM4EAGTR1RORC | |
| SCHEMBL365259 | 0.77 | KDM4E (0.44) | EGFRSRCKDM4EAGTR1ELANE | |
| SCHEMBL365256 | 0.74 | EGFR (0.40) | EGFRSRCALDH1A1 | |
| SCHEMBL367766 | 0.74 | L3MBTL1 (0.43) | EGFRSRCHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |