Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.39 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | BAZ2B | Q9UIF8 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL367222 | 0.92 | EGFR (0.41) | EGFRSRCELANEPOLBPARP1 | |
| SCHEMBL366821 | 0.90 | AGTR1 (0.41) | EGFRAGTR1SRCPOLBCYP2C19 | |
| SCHEMBL365023 | 0.89 | EGFR (0.40) | EGFRAGTR1SRCELANECYP3A4 | |
| SCHEMBL365789 | 0.88 | EGFR (0.41) | EGFRAGTR1SRCPOLBKDM4E | |
| SCHEMBL365771 | 0.84 | EGFR (0.43) | EGFRSRCPOLBMAPTKDM4E | |
| SCHEMBL366790 | 0.83 | EGFR (0.41) | EGFRAGTR1SRCPOLBHSD17B10 | |
| SCHEMBL367750 | 0.82 | ATM (0.43) | EGFRPOLBMAPTL3MBTL1KDM4E | |
| SCHEMBL366116 | 0.78 | CA1 (0.41) | EGFRAGTR1 | |
| SCHEMBL366811 | 0.77 | EGFR (0.44) | EGFRAGTR1SRCELANEPOLB | |
| SCHEMBL367766 | 0.74 | L3MBTL1 (0.43) | EGFRSRCPARP1MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |