Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.33 |
| ▸ | CSF1R | P07333 | 4/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 4/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.33 |
| ▸ | FLT3 | P36888 | 4/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 4/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.33 |
| ▸ | CDK2 | P24941 | 4/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.33 |
| ▸ | PAK4 | O96013 | 3/20 | 0.33 |
| ▸ | PIM1 | P11309 | 3/20 | 0.33 |
| ▸ | PRKACA | P17612 | 3/20 | 0.33 |
| ▸ | SYK | P43405 | 3/20 | 0.33 |
| ▸ | CLK2 | P49760 | 3/20 | 0.33 |
| ▸ | CDK9 | P50750 | 3/20 | 0.33 |
| ▸ | JAK3 | P52333 | 3/20 | 0.33 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.33 |
| ▸ | STK3 | Q13188 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5017650 | 0.71 | NPC1 (0.55) | RAB9ACDK2SYKSMN1; SMN2JAK2 | |
| SCHEMBL79935 | 0.70 | CSF1R (0.39) | RAB9ACSF1RFLT3ROCK1CDK2 | |
| SCHEMBL5015389 | 0.68 | DEGS1 (0.48) | RAB9ACDK5CDK2NPC1MAPK1 | |
| SCHEMBL81783 | 0.68 | CSF1R (0.40) | RAB9ACSF1RDAPK3MAP4K4FLT3 | |
| SCHEMBL3415683 | 0.67 | CDK2 (0.55) | RAB9ACSF1RMAP4K4FLT3CDK5 | |
| SCHEMBL5014883 | 0.67 | CSF1R (0.36) | RAB9ACSF1RFLT3ROCK1CDK2 | |
| SCHEMBL3646898 | 0.66 | ROCK2 (0.36) | RAB9ADAPK3MAP4K4FLT3CSNK1A1 | |
| SCHEMBL5013515 | 0.66 | CCNE1 (0.50) | RAB9AROCK1CDK2ROCK2AURKA | |
| SCHEMBL82345 | 0.66 | CSF1R (0.39) | RAB9ACSF1RFLT3ROCK1CDK2 | |
| SCHEMBL5014078 | 0.66 | SMN1; SMN2 (0.57) | RAB9ASMN1; SMN2NPC1KDM4EEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100249067-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC. (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249067-A1 | Modulators of Mitotic Kinases | BUB1, BUB1B, CDK1 | RAB9A 2076/4885CSF1R 2610/4885DAPK3 498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.