Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 2/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | PAK4 | O96013 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3415683 | 0.71 | CDK2 (0.55) | RAB9ANPC1JAK2CDK2MAPT | |
| SCHEMBL5017650 | 0.71 | NPC1 (0.55) | RAB9ANPC1JAK2BRAFCDK2 | |
| SCHEMBL5013515 | 0.68 | CCNE1 (0.50) | ROCK2ROCK1RAB9ACDK2MAPT | |
| SCHEMBL3651264 | 0.68 | ROCK2 (0.43) | ROCK2ROCK1RAB9ANPC1JAK2 | |
| SCHEMBL3651268 | 0.66 | RAB9A (0.33) | ROCK2ROCK1RAB9ANPC1JAK2 | |
| SCHEMBL5014078 | 0.66 | SMN1; SMN2 (0.57) | RAB9ANPC1SMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL5015389 | 0.65 | DEGS1 (0.48) | RAB9ANPC1CDK2ALDH1A1HDAC6 | |
| SCHEMBL31412961 | 0.62 | ROCK2 (0.47) | ROCK2ROCK1CDK2L3MBTL1AURKA | |
| SCHEMBL6774592 | 0.61 | MAPT (0.51) | RAB9ANPC1SMN1; SMN2ALOX15MAPT | |
| SCHEMBL80255 | 0.60 | ROCK2 (0.43) | ROCK2ROCK1RAB9ANPC1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100249067-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC. (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249067-A1 | Modulators of Mitotic Kinases | BUB1, BUB1B, CDK1 | ROCK2 501/4885ROCK1 365/4885RAB9A 2076/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.