Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRC | Q99895 | 3/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.44 |
| ▸ | RXRA | P19793 | 2/20 | 0.44 |
| ▸ | RXRB | P28702 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.43 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.40 |
| ▸ | CDH1 | P12830 | 1/20 | 0.40 |
| ▸ | APC | P25054 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL733156 | 0.87 | DHODH (0.49) | CTRCMAP2K4P2RY14DHODH | |
| SCHEMBL2513525 | 0.87 | EGFR (0.47) | RXRARXRBTSHR | |
| SCHEMBL2516837 | 0.87 | DHODH (0.46) | CHEK2RXRARXRBAURKATPX2 | |
| SCHEMBL491311 | 0.87 | AHR (0.41) | CA12ALPLMAP4K4 | |
| SCHEMBL3654429 | 0.86 | DHODH (0.50) | CTRCALPLRXRARXRBMAP2K4 | |
| SCHEMBL3653446 | 0.84 | MARS1 (0.49) | ALPLAURKATPX2MAP2K4 | |
| SCHEMBL3650607 | 0.84 | ALDH1A1 (0.39) | CTRCNOTUMCA12ALPLAURKA | |
| SCHEMBL2513559 | 0.83 | ALOX15 (0.36) | NOTUMCA12MAP2K4ALOX15TSHR | |
| SCHEMBL3650536 | 0.83 | ALPL (0.48) | ALPLCHEK2RXRAMAP4K4MCL1 | |
| SCHEMBL3658838 | 0.82 | KMO (0.41) | CA12ALPLAURKATPX2MAP2K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205573-A1 | TETRAZOLE-SUBSTITUTED ARYL AMIDE DERIVATIVES AND USES THEREOF | F. Hoffmann-Roche AG (CH) | 2010-07-14 | — | — | EP | claimed |
| WO-2009043780-A1 | TETRAZOLE-SUBSTITUTED ARYL AMIDE DERIVATIVES AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-09 | — | — | WO | claimed |
| EP-2205573-A1 | TETRAZOLE-SUBSTITUTED ARYL AMIDE DERIVATIVES AND USES THEREOF | F. Hoffmann-Roche AG (CH) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009043780-A1 | TETRAZOLE-SUBSTITUTED ARYL AMIDE DERIVATIVES AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-09 | — | — | WO | disclosed |