SCHEMBL3653446

SCHEMBL3653446

O=C(O)c1cc(-c2nnn[nH]2)cc(-c2ccc(Cl)cc2Cl)c1

nearest known ligand 0.49

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MARS1 P56192 7/20 0.49
SRD5A2 P31213 1/20 0.49
ALPL P05186 6/20 0.47
KDM4E B2RXH2 1/20 0.41
NPC1 O15118 1/20 0.41
CRHBP P24387 1/20 0.41
RAB9A P51151 1/20 0.41
CRHR2 Q13324 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
POLB P06746 1/20 0.40
GPR55 Q9Y2T6 1/20 0.40
AHR P35869 1/20 0.39
MAP2K4 P45985 1/20 0.37
AURKA O14965 1/20 0.37
TPX2 Q9ULW0 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3650607 0.90 ALDH1A1 (0.39) MARS1SRD5A2ALPLMAP2K4AURKA
SCHEMBL3658374 0.88 EIF4E (0.38) MARS1SRD5A2ALPLNPC1RAB9A
SCHEMBL3660881 0.88 AXL (0.38) MARS1SRD5A2ALPLMAP2K4
SCHEMBL3658838 0.88 KMO (0.41) MARS1SRD5A2ALPLMAP2K4AURKA
SCHEMBL3655999 0.86 ALPL (0.46) ALPLKDM4ENPC1RAB9ASMN1; SMN2
SCHEMBL3652199 0.84 CTRC (0.47) ALPLMAP2K4AURKATPX2
SCHEMBL3652824 0.82 ALDH1A1 (0.44) KDM4ESMN1; SMN2POLB
SCHEMBL3652133 0.81 CTSA (0.40) ALPLNPC1RAB9ASMN1; SMN2
SCHEMBL2513559 0.79 ALOX15 (0.36) KDM4ENPC1RAB9ASMN1; SMN2MAP2K4
SCHEMBL8779218 0.79 SRD5A2 (0.68) MARS1SRD5A2ALPLKDM4ENPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2205573-A1 TETRAZOLE-SUBSTITUTED ARYL AMIDE DERIVATIVES AND USES THEREOF F. Hoffmann-Roche AG (CH) 2010-07-14 EP claimed
WO-2009043780-A1 TETRAZOLE-SUBSTITUTED ARYL AMIDE DERIVATIVES AND USES THEREOF F. HOFFMANN-LA ROCHE AG (CH) 2009-04-09 WO claimed
EP-2234989-A1 TETRAZOLE-SUBSTITUTED ARYLAMIDE DERIVATIVES AND THEIR USE AS P2X3 AND/OR P2X2/3 PURINERGIC RECEPTOR ANTAGONISTS F. Hoffmann-La Roche AG (CH) 2010-10-06 EP disclosed
EP-2205573-A1 TETRAZOLE-SUBSTITUTED ARYL AMIDE DERIVATIVES AND USES THEREOF F. Hoffmann-Roche AG (CH) 2010-07-14 EP disclosed
WO-2009077371-A1 TETRAZOLE-SUBSTITUTED ARYLAMIDE DERIVATIVES AND THEIR USE AS P2X3 AND/OR P2X2/3 PURINERGIC RECEPTOR ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2009-06-25 WO disclosed
WO-2009043780-A1 TETRAZOLE-SUBSTITUTED ARYL AMIDE DERIVATIVES AND USES THEREOF F. HOFFMANN-LA ROCHE AG (CH) 2009-04-09 WO disclosed
EP-2038264-A1 TETRAZOLE-SUBSTITUTED ARYLAMIDES F.HOFFMANN-LA ROCHE AG (CH) 2009-03-25 EP disclosed
WO-2008000645-A1 TETRAZOLE-SUBSTITUTED ARYLAMIDES F. HOFFMANN-LA ROCHE AG (CH) 2008-01-03 WO disclosed