Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 3/20 | 0.39 |
| ▸ | MARS1 | P56192 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.37 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.37 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | EIF4E | P06730 | 1/20 | 0.35 |
| ▸ | F11 | P03951 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | CTRC | Q99895 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3653446 | 0.90 | MARS1 (0.49) | ALPLMARS1SRD5A2AURKATPX2 | |
| SCHEMBL3655999 | 0.86 | ALPL (0.46) | TP53ALPLCTRC | |
| SCHEMBL3658838 | 0.85 | KMO (0.41) | ALPLMARS1SRD5A2AURKATPX2 | |
| SCHEMBL3652824 | 0.85 | ALDH1A1 (0.44) | ALDH1A1 | |
| SCHEMBL3652199 | 0.84 | CTRC (0.47) | ALPLAURKATPX2MAP2K4CA12 | |
| SCHEMBL3652133 | 0.81 | CTSA (0.40) | ALDH1A1ALPLHDAC6EIF4ECNR2 | |
| SCHEMBL3211407 | 0.81 | TSHR (0.42) | ALDH1A1ALPLSRD5A2AURKATPX2 | |
| SCHEMBL3660881 | 0.81 | AXL (0.38) | ALDH1A1ALPLMARS1SRD5A2MAP2K4 | |
| SCHEMBL3658374 | 0.81 | EIF4E (0.38) | TP53ALPLMARS1SRD5A2MAP2K4 | |
| SCHEMBL2513559 | 0.79 | ALOX15 (0.36) | ALDH1A1TP53MAP2K4CA12MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205573-A1 | TETRAZOLE-SUBSTITUTED ARYL AMIDE DERIVATIVES AND USES THEREOF | F. Hoffmann-Roche AG (CH) | 2010-07-14 | — | — | EP | claimed |
| WO-2009043780-A1 | TETRAZOLE-SUBSTITUTED ARYL AMIDE DERIVATIVES AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-09 | — | — | WO | claimed |
| EP-2205573-A1 | TETRAZOLE-SUBSTITUTED ARYL AMIDE DERIVATIVES AND USES THEREOF | F. Hoffmann-Roche AG (CH) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009043780-A1 | TETRAZOLE-SUBSTITUTED ARYL AMIDE DERIVATIVES AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-09 | — | — | WO | disclosed |