Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | PDE7A | Q13946 | 7/20 | 0.45 |
| ▸ | PDE7B | Q9NP56 | 4/20 | 0.45 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | KDM4B | O94953 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29880479 | 0.85 | MAPK1 (0.58) | MAPK1TSHRVCAM1ALDH1A1L3MBTL1 | |
| SCHEMBL16952297 | 0.85 | MAPK1 (0.58) | MAPK1TSHRVCAM1ALDH1A1L3MBTL1 | |
| SCHEMBL11741496 | 0.85 | MAPK1 (0.57) | MAPK1TSHRVCAM1ALDH1A1L3MBTL1 | |
| SCHEMBL11741510 | 0.85 | MAPK1 (0.57) | MAPK1TSHRVCAM1ALDH1A1L3MBTL1 | |
| SCHEMBL203086 | 0.83 | MAPK1 (0.55) | MAPK1TSHRVCAM1ALDH1A1L3MBTL1 | |
| SCHEMBL29708112 | 0.83 | MAPK1 (0.55) | MAPK1TSHRVCAM1ALDH1A1L3MBTL1 | |
| SCHEMBL5170556 | 0.81 | MAPK1 (0.53) | MAPK1TSHRVCAM1ALDH1A1L3MBTL1 | |
| SCHEMBL30929373 | 0.79 | ALDH1A1 (0.57) | MAPK1TSHRALDH1A1LMNAPOLB | |
| SCHEMBL17341954 | 0.79 | ALDH5A1 (0.44) | MAPK1VCAM1ALDH1A1POLBKDM4A | |
| SCHEMBL6410654 | 0.79 | ALDH1A1 (0.57) | MAPK1TSHRALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113509959-A | Preparation method of hollow mesoporous nano silicon spheres for packaging chiral catalyst, product and application thereof | 重庆邮电大学 | 2021-10-19 | — | — | CN | disclosed |
| CN-107641086-B | Synthetic method of nitroolefin compound | 浙江工业大学 | 2020-05-22 | — | — | CN | disclosed |
| CN-107641086-A | A kind of synthetic method of nitro compds hydrocarbon compound | 浙江工业大学 | 2018-01-30 | — | — | CN | disclosed |
| CN-105085520-B | 3 (2 nitro, 1 phenethyl) 2 (2 phenylimidazoles simultaneously [1,2 α] pyridine) class compound | 郑州大学 | 2017-03-29 | — | — | CN | disclosed |
| EP-2632269-B1 | CYCLIC AMINE SUBSTITUTED OXAZOLIDINONES AS CETP INHIBITORS | MERCK SHARP & DOHME (US) | 2017-03-15 | — | — | EP | disclosed |
| US-9221834-B2 | Cyclic amine substituted oxazolidinone CETP inhibitor | MERCK SHARP & DOHME CORP. (US) | 2015-12-29 | — | — | US | disclosed |
| US-20130331372-A1 | Cyclic Amine Substituted Oxazolidinone CETP Inhibitor | MERCK SHARP & DOHME CORP. | 2013-12-12 | — | — | US | disclosed |
| EP-2632269-A1 | CYCLIC AMINE SUBSTITUTED OXAZOLIDINONE CETP INHIBITOR | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | disclosed |
| US-8293926-B2 | Method of producing optically active 4-amino-3-substituted phenylbutanoic acid | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-10-23 | — | — | US | disclosed |
| WO-2012058187-A1 | CYCLIC AMINE SUBSTITUTED OXAZOLIDINONE CETP INHIBITOR | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |
| WO-2012009372-A2 | TRIAZOLIUM CARBENE CATALYSTS AND PROCESSES FOR ASYMMETRIC CARBON-CARBON BOND FORMATION | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-01-19 | — | — | WO | disclosed |
| US-20100130795-A1 | METHOD FOR PRODUCING BETA-NITROSTYRENE COMPOUND | SUMITOMO CHEMICAL COMPANY LIMITED | 2010-05-27 | — | — | US | disclosed |
| US-20090137819-A1 | Method of Producing Optically Active 4-Amino-3-Substituted Phenylbutanoic Acid | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130795-A1 | METHOD FOR PRODUCING BETA-NITROSTYRENE COMPOUND | NAT1, NOS1, NOS2 | MAPK1 2077/4885TSHR 3999/4885VCAM1 2734/4885 |
| US-20130331372-A1 | Cyclic Amine Substituted Oxazolidinone CETP Inhibitor | CETP, APOB, MTTP | MAPK1 2630/4885TSHR 3756/4885VCAM1 1215/4885 |
| US-20090137819-A1 | Method of Producing Optically Active 4-Amino-3-Substituted Phenylbutanoic Acid | ALAD, ATP6V1B1, DAO | MAPK1 1331/4885TSHR 3212/4885VCAM1 2691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.