Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364594 | 0.87 | EGFR (0.44) | KDM4EKMT2AEGFRMAPTSMN1; SMN2 | |
| SCHEMBL365565 | 0.87 | KMT2A (0.52) | KDM4EKMT2AGAAMAPTSMN1; SMN2 | |
| SCHEMBL364207 | 0.85 | EGFR (0.47) | KDM4ECHRM1KMT2AEGFRGAA | |
| SCHEMBL367564 | 0.82 | HPGD (0.50) | KDM4EKMT2ASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL364969 | 0.82 | KDM4E (0.53) | KDM4EKMT2AGAAMAPTHTT | |
| SCHEMBL366828 | 0.82 | PKM (0.46) | KMT2AEGFRGAAALDH1A1NPSR1 | |
| SCHEMBL366362 | 0.82 | SMN1; SMN2 (0.54) | KDM4EKMT2AEGFRMAPTSMN1; SMN2 | |
| SCHEMBL365591 | 0.81 | HPGD (0.49) | KDM4EKMT2ASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL365544 | 0.79 | REN (0.53) | — | |
| SCHEMBL366310 | 0.79 | ALDH1A1 (0.52) | KDM4EKMT2AMAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |