Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TPMT | P51580 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28391599 | 1.00 | KDM4E (0.32) | KDM4EKMT2ATPMTCYP1A2LMNA | |
| SCHEMBL377437 | 0.97 | TPMT (0.33) | KDM4EKMT2ATPMTCYP1A2LMNA | |
| SCHEMBL6397169 | 0.95 | KDM4E (0.32) | KDM4EKMT2ATPMTCYP1A2LMNA | |
| SCHEMBL621486 | 0.92 | TPMT (0.33) | KDM4EKMT2ATPMTCYP1A2LMNA | |
| SCHEMBL6389935 | 0.90 | KDM4E (0.32) | KDM4EKMT2ATPMTCYP1A2LMNA | |
| SCHEMBL3664084 | 0.88 | LMNA (0.32) | LMNA | |
| SCHEMBL31086827 | 0.86 | TPMT (0.33) | KDM4EKMT2ATPMTCYP1A2LMNA | |
| SCHEMBL3728638 | 0.86 | — | — | |
| SCHEMBL12957727 | 0.86 | — | — | |
| SCHEMBL3830951 | 0.86 | LMNA (0.34) | KDM4EKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 136 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3548461-B1 | MECHANOCHEMICAL SYNTHESIS OF RADIOGRAPHIC AGENTS INTERMEDIATES | BRACCO IMAGING SPA (IT) | 2021-02-03 | — | — | EP | claimed |
| US-10836710-B2 | Mechanochemical synthesis of radiographic agents intermediates | BRACCO IMAGING SPA (IT) | 2020-11-17 | — | — | US | claimed |
| US-20200079728-A1 | MECHANOCHEMICAL SYNTHESIS OF RADIOGRAPHIC AGENTS INTERMEDIATES | BRACCO IMAGING SPA (IT) | 2020-03-12 | — | — | US | claimed |
| US-8624061-B2 | Process for the preparation of iodinated contrast agent | BRACCO IMAGING S.P.A. (IT) | 2014-01-07 | — | — | US | claimed |
| EP-0901460-B1 | A PROCESS FOR THE PREPARATION OF 5-AMINO-2,4,6-TRIIODO-1,3-BENZENEDICARBOXYLIC ACID DERIVATIVES | BRACCO IMAGING SPA (IT) | 2002-09-18 | — | — | EP | claimed |
| EP-0851854-B1 | PROCESS FOR THE PURIFICATION OF AN INTERMEDIATE IN THE PREPARATION OF IOPAMIDOL | BRACCO IMAGING SPA (IT) | 2001-12-12 | — | — | EP | claimed |
| EP-0773925-B1 | PROCESS FOR THE PREPARATION OF A DICARBOXYLIC ACID DICHLORIDE | FRUCTAMINE SPA (IT) | 2000-02-09 | — | — | EP | claimed |
| EP-0794937-B1 | PROCESS FOR PREPARING 5-AMINO-2,4,6-TRIIODOISOPHTHALIC ACID DICHLORIDE BY CHLORINATION OF THE CORRESPONDING ACID IN THE PRESENCE OF A TERTIARY AMINE SALT OR QUARTERNARY AMMONIUM SALT | BRACCO INT BV (NL) | 1999-04-07 | — | — | EP | claimed |
| EP-0773924-B1 | PROCESS FOR THE PREPARATION OF A DICARBOXYLIC ACID DICHLORIDE | FRUCTAMINE SPA (IT) | 1999-02-10 | — | — | EP | claimed |
| US-5856570-A | Process for preparing 5-amino-2,4,6-triiodoisophthalic acid dichloride by chlorination of the corresponding acid in the presence of a tertiary amine salt or quaternary ammonium salt | BRACCO INTERNATIONAL B.V. (NL) | 1999-01-05 | — | — | US | claimed |
| US-5672735-A | 5-((ACETYLOXY)-1-OXOPROPYL)AMINO)-2,4,6-TRIIODO-1,3-BENZENEDI CARBONYL CHLORIDE BY REACTING 5-AMINO-2,4,6-TRIIODOBENZENE DICARBONYL CHLORIDE WITH THE PROPIONYL CHLORIDE COMPOUND USING AN APROTIC DIPOLAR SOLVENT AND HALOHYDRIC ACID CATALYST | FRUCTAMINE S.P.A. (IT) | 1997-09-30 | — | — | US | claimed |
| US-5663432-A | CATALYZED BY A TETRAALKYLAMMONIUM SALT | ZAMBON GROUP S.P.A. (IT) | 1997-09-02 | — | — | US | claimed |
| EP-0773925-A1 | PROCESS FOR THE PREPARATION OF A DICARBOXYLIC ACID DICHLORIDE | Fructamine S.P.A. (IT) | 1997-05-21 | — | — | EP | claimed |
| EP-0773924-A1 | PROCESS FOR THE PREPARATION OF A DICARBOXYLIC ACID DICHLORIDE | Fructamine S.P.A. (IT) | 1997-05-21 | — | — | EP | claimed |
| US-5616795-A | REACTING 5-AMINO-2,4,6-TRIIODO-1,3-BENZENEDICARBOXLYIC ACID AND THIONYL CHLORIDE IN SOLVENT WITH TERTIARY AMINE CATALYST | FRUCTAMINE S.P.A. (IT) | 1997-04-01 | — | — | US | claimed |
| US-5580993-A | Process for the preparation of iopamidol and 5-amino-2,2-dialkyl-1,3-dioxanes | ZAMBON GROUP S.P.A. (IT) | 1996-12-03 | — | — | US | claimed |
| WO-1996037459-A1 | PROCESS FOR THE PREPARATION OF A DICARBOXYLIC ACID DICHLORIDE | FRUCTAMINE S.P.A. (IT) | 1996-11-28 | — | — | WO | claimed |
| WO-1996037460-A1 | PROCESS FOR THE PREPARATION OF A DICARBOXYLIC ACID DICHLORIDE | FRUCTAMINE S.P.A. (IT) | 1996-11-28 | — | — | WO | claimed |
| WO-1996036590-A1 | PROCESS FOR THE PREPARATION OF 5-AMINO-2,4,6-TRIIODOISOPHTHALIC ACID DICHLORIDE BY CHLORINATION WITH THIONYL CHLORIDE IN THE PRESENCE OF A CATALYST | BRACCO INTERNATIONAL B:V. (NL) | 1996-11-21 | — | — | WO | claimed |
| US-5362905-A | Process for the preparation of L-5-(2-acetoxy-propionylamino)-2,4,6-triiodo-isophthalic acid dichloride | ZAMBON GROUP S.P.A. (IT) | 1994-11-08 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10836710-B2 | Mechanochemical synthesis of radiographic agents intermediates | ALG1, OGT, MPI | KDM4E 4565/4885KMT2A 3770/4885TPMT 2768/4885 |
| US-20200079728-A1 | MECHANOCHEMICAL SYNTHESIS OF RADIOGRAPHIC AGENTS INTERMEDIATES | ALG1, OGT, MPI | KDM4E 4565/4885KMT2A 3770/4885TPMT 2768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.