SCHEMBL377437

SCHEMBL377437

Nc1c(I)c(C(=O)O)c(I)c(C(=O)O)c1I

nearest known ligand 0.33

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
TPMT P51580 1/20 0.33
KDM4E B2RXH2 1/20 0.33
KMT2A Q03164 1/20 0.33
CYP1A2 P05177 1/20 0.32
LMNA P02545 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6397169 0.97 KDM4E (0.32) TPMTKDM4EKMT2ACYP1A2LMNA
Hydrochloric Acid SCHEMBL620189 0.97 KDM4E (0.32) TPMTKDM4EKMT2ACYP1A2LMNA
Hydrochloric Acid SCHEMBL28391599 0.97 KDM4E (0.32) TPMTKDM4EKMT2ACYP1A2LMNA
SCHEMBL621486 0.94 TPMT (0.33) TPMTKDM4EKMT2ACYP1A2LMNA
SCHEMBL6389935 0.92 KDM4E (0.32) TPMTKDM4EKMT2ACYP1A2LMNA
SCHEMBL3664084 0.91 LMNA (0.32) LMNA
SCHEMBL31086827 0.89 TPMT (0.33) TPMTKDM4EKMT2ACYP1A2LMNA
SCHEMBL3830951 0.89 LMNA (0.34) KDM4EKMT2ALMNA
SCHEMBL3728638 0.89
SCHEMBL12957727 0.89

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 787 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12630664-B2 Chemically modified shape memory polymer embolic foams with increased X-ray visualization THE TEXAS A&M UNIVERSITY SYSTEM (US) 2026-05-19 US claimed
EP-3595581-B1 VASCULAR PROSTHESIS FOR LEAK PREVENTION DURING ENDOVASCULAR ANEURYSM REPAIR TEXAS A & M UNIV SYS (US) 2026-02-25 EP claimed
US-12559585-B2 Radiopaque thermoplastic polymer THE TEXAS A&M UNIVERSITY SYSTEM (US) 2026-02-24 US claimed
EP-4656211-A2 COMPOSITIONS FOR EMBOLIZATION Iberhospitex, S.A. (ES) 2025-12-03 EP claimed
EP-4376905-B1 COMPOSITIONS FOR EMBOLIZATION IBERHOSPITEX SA (ES) 2025-10-22 EP claimed
CN-120053643-A Preparation and application of radiotherapy sensitizer IR808-ATIPA 中国医科大学附属盛京医院 2025-05-30 CN claimed
US-12251500-B2 Vascular prosthesis for leak prevention during endovascular aneurysm repair THE TEXAS A&M UNIVERSITY SYSTEM (US) 2025-03-18 US claimed
CN-119523914-A Developing embolism microsphere and preparation method and application thereof 科睿驰(深圳)医疗科技发展有限公司 2025-02-28 CN claimed
US-20240416011-A1 Drug Eluting Shape Memory Foam THE TEXAS A&M UNIVERSITY SYSTEM 2024-12-19 US claimed
US-20240358885-A1 COMPOSITIONS FOR EMBOLIZATION IBERHOSPITEX, S.A. (ES) 2024-10-31 US claimed
WO-1996037458-A1 PROCESS FOR THE PREPARATION OF A HALOSUBSTITUTED AROMATIC ACID FRUCTAMINE S.P.A. (IT) 1996-11-28 WO claimed
WO-1996037459-A1 PROCESS FOR THE PREPARATION OF A DICARBOXYLIC ACID DICHLORIDE FRUCTAMINE S.P.A. (IT) 1996-11-28 WO claimed
WO-1996036590-A1 PROCESS FOR THE PREPARATION OF 5-AMINO-2,4,6-TRIIODOISOPHTHALIC ACID DICHLORIDE BY CHLORINATION WITH THIONYL CHLORIDE IN THE PRESENCE OF A CATALYST BRACCO INTERNATIONAL B:V. (NL) 1996-11-21 WO claimed
EP-0673922-A1 Non-ionic iodinated dimers as X-ray contrast agents, process for their preparation and pharmaceutical compositions containing them CENTRO INVESTIGACION JUSTESA IMAGEN S.A. (ES) 1995-09-27 EP claimed
US-5160725-A Contrast agent for diagnostic imaging, polyethylene glycol phosphates and carboxylates as stabilizers SILICA GEL GESELLSCHAFT MBH ADSORPTIONS-TECHNIK, APPARATEBAU (DE) 1992-11-03 US claimed
EP-0284549-B1 MAGNETIC FLUID COMPOSITIONS Silica Gel Ges.mbH Absorptionstechnik, Apparatebau (DE) 1992-07-15 EP claimed
EP-0083964-B1 COMPOUNDS SUITABLE FOR X-RAY VISUALISATION METHODS Mallinckrodt, Inc. (a Delaware corporation) (US) 1986-04-16 EP claimed
EP-0083964-A1 Compounds suitable for X-ray visualisation methods Mallinckrodt, Inc. (a Delaware corporation) (US) 1983-07-20 EP claimed
EP-0022744-B1 TRI-IODATED BASES, THEIR PREPARATION AND X-RAY CONTRAST AGENT CONTAINING THEM SCHERING AKTIENGESELLSCHAFT (DE) 1983-03-23 EP claimed
US-4283381-A OPAQUING AGENTS SCHERING AKTIENGESELLSCHAFT (DE) 1981-08-11 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12559585-B2 Radiopaque thermoplastic polymer DCX, TPO, TAAR5 TPMT 1437/4885KDM4E 2622/4885KMT2A 1964/4885
US-12630664-B2 Chemically modified shape memory polymer embolic foams with increased X-ray visualization LSM8, U2SURP, TAS2R8 TPMT 572/4885KDM4E 3070/4885KMT2A 2426/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.