Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL366998 | 0.90 | HTT (0.46) | HTTMAPK1LMNAKDM4EMEN1 | |
| SCHEMBL367746 | 0.87 | EGFR (0.43) | LMNAKDM4EIDO1MEN1KMT2A | |
| SCHEMBL364786 | 0.86 | IDO1 (0.46) | HTTMAPK1LMNAKDM4EIDO1 | |
| SCHEMBL365647 | 0.84 | IDO1 (0.43) | LMNAKDM4EIDO1MEN1KMT2A | |
| SCHEMBL366132 | 0.83 | ALDH1A1 (0.38) | KDM4EIDO1MEN1KMT2AAGTR1 | |
| SCHEMBL366462 | 0.81 | LMNA (0.46) | HTTLMNAKDM4EAKR1B1MEN1 | |
| SCHEMBL365146 | 0.80 | IDO1 (0.40) | KDM4EIDO1MEN1KMT2AAGTR1 | |
| SCHEMBL367204 | 0.78 | RORC (0.43) | KDM4EIDO1MEN1KMT2AMAPT | |
| SCHEMBL366887 | 0.76 | KDM4E (0.56) | HTTLMNAKDM4EIDO1MEN1 | |
| SCHEMBL365934 | 0.76 | KDM4E (0.45) | HTTLMNAKDM4EIDO1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |