SCHEMBL3667374

SCHEMBL3667374

Cc1oc(-c2ccccc2)c(Br)c1C=O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.40
KMT2A Q03164 5/20 0.40
PLA2G1B P04054 1/20 0.40
ATG4B Q9Y4P1 1/20 0.40
RAB9A P51151 1/20 0.36
NTSR1 P30989 1/20 0.35
GPR55 Q9Y2T6 1/20 0.35
ALDH1A1 P00352 5/20 0.35
LMNA P02545 2/20 0.35
NPSR1 Q6W5P4 1/20 0.34
PTGS2 P35354 3/20 0.34
NR4A2 P43354 3/20 0.34
RXRA P19793 2/20 0.34
RXRB P28702 2/20 0.34
POLB P06746 2/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2C9 P11712 1/20 0.34
TSHR P16473 1/20 0.34
CYP2C19 P33261 1/20 0.34
TDP1 Q9NUW8 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12790881 0.76 PTGS2 (0.42) MEN1KMT2ARAB9AALDH1A1LMNA
SCHEMBL3666080 0.71 ALDH1A1 (0.46) MEN1KMT2ARAB9AALDH1A1LMNA
SCHEMBL21661959 0.69 AR (0.40) RAB9ANTSR1GPR55ALDH1A1LMNA
SCHEMBL13760654 0.68 MAPT (0.44) MEN1KMT2APLA2G1BATG4BRAB9A
SCHEMBL6518530 0.68 PTGS1 (0.51) MEN1KMT2ARAB9AALDH1A1LMNA
SCHEMBL3982046 0.67 ALDH1A1 (0.46) MEN1KMT2ARAB9AALDH1A1NPSR1
SCHEMBL21661958 0.66 LMNA (0.41) MEN1KMT2ARAB9ANTSR1GPR55
SCHEMBL29193615 0.66 ALOX5 (0.39) MEN1KMT2APLA2G1BATG4BALDH1A1
SCHEMBL1554147 0.64 DDR2 (0.57) MEN1KMT2ARAB9AALDH1A1LMNA
SCHEMBL3064394 0.64 CYP2A6 (0.43) MEN1KMT2APLA2G1BATG4BRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110052805-A1 METHOD AND SYSTEM FOR DEPOSITING A METAL OR METALLOID ON CARBON NANOTUBES ARKEMA FRANCE (FR) 2011-03-03 US claimed
US-20110054017-A1 SUBSTITUTED FURANS AND THEIR USE BAYER INTELLECTUAL PROPERTY GMBH (DE) 2011-03-03 US disclosed
US-20110054017-A1 SUBSTITUTED FURANS AND THEIR USE BAYER INTELLECTUAL PROPERTY GMBH (DE) 2011-03-03 US disclosed
US-20110054017-A1 SUBSTITUTED FURANS AND THEIR USE BAYER INTELLECTUAL PROPERTY GMBH (DE) 2011-03-03 US disclosed
EP-2240461-A1 SUBSTITUTED FURANS AND USE THEREOF Bayer Schering Pharma Aktiengesellschaft (DE) 2010-10-20 EP disclosed
WO-2009097991-A1 SUBSTITUTED FURANS AND USE THEREOF BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2009-08-13 WO disclosed
WO-2009097991-A1 SUBSTITUTED FURANS AND USE THEREOF BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2009-08-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110054017-A1 SUBSTITUTED FURANS AND THEIR USE XDH, TXN2, FABP3 MEN1 1583/4885KMT2A 4756/4885PLA2G1B 897/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.