Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KIFC1 | Q9BW19 | 3/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44745 | 0.85 | HDAC6 (0.41) | L3MBTL1CYP19A1 | |
| SCHEMBL44571 | 0.85 | NOTUM (0.47) | L3MBTL1CYP19A1TP53SMN1; SMN2THRB | |
| SCHEMBL44368 | 0.83 | SMN1; SMN2 (0.43) | L3MBTL1TP53SMN1; SMN2THRBMAPT | |
| SCHEMBL44399 | 0.80 | KCNH2 (0.40) | CYP19A1TP53SMN1; SMN2THRBKIFC1 | |
| SCHEMBL44656 | 0.78 | MAPT (0.41) | THRBMAPTPOLBLMNARAB9A | |
| SCHEMBL3667489 | 0.77 | F2RL3 (0.54) | CYP19A1TP53SMN1; SMN2THRBMAPT | |
| SCHEMBL44509 | 0.77 | L3MBTL1 (0.60) | L3MBTL1TP53SMN1; SMN2BACE1BACE2 | |
| SCHEMBL13130238 | 0.77 | L3MBTL1 (1.00) | L3MBTL1TP53SMN1; SMN2TRPM8MAPT | |
| SCHEMBL11030523 | 0.75 | TP53 (0.59) | CYP19A1TP53SMN1; SMN2THRBMAPT | |
| SCHEMBL44391 | 0.75 | THRB (0.44) | THRBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |