Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44302 | 0.89 | SMN1; SMN2 (0.50) | ALDH1A1TP53SMN1; SMN2MAPTUSP2 | |
| SCHEMBL44918 | 0.86 | CYP19A1 (0.44) | ALDH1A1TP53SMN1; SMN2MAPTUSP2 | |
| SCHEMBL39342 | 0.86 | CYP19A1 (0.53) | ALDH1A1TP53SMN1; SMN2MAPTUSP2 | |
| SCHEMBL44139 | 0.85 | ALDH1A1 (0.43) | ALDH1A1HSD11B1TP53SMN1; SMN2MAPT | |
| SCHEMBL39660 | 0.84 | CYP19A1 (0.56) | ALDH1A1TP53MAPTLMNACYP19A1 | |
| SCHEMBL44636 | 0.83 | TP53 (0.43) | ALDH1A1TP53SMN1; SMN2MAPTUSP2 | |
| SCHEMBL44557 | 0.83 | KMT2A (0.40) | ALDH1A1TP53SMN1; SMN2MAPTUSP2 | |
| SCHEMBL45229 | 0.81 | TP53 (0.41) | ALDH1A1PKMTP53SMN1; SMN2MAPT | |
| SCHEMBL3667489 | 0.79 | F2RL3 (0.54) | TP53SMN1; SMN2MAPTLMNACYP19A1 | |
| SCHEMBL44483 | 0.79 | RAB9A (0.52) | ALDH1A1TP53SMN1; SMN2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |