Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 7/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL366831 | 0.93 | MCL1 (0.35) | MCL1SMN1; SMN2KMT2APSEN1PSEN2 | |
| SCHEMBL366906 | 0.85 | HTT (0.37) | MCL1SMN1; SMN2KMT2APSEN1PSEN2 | |
| SCHEMBL364641 | 0.83 | PLK1 (0.38) | SMN1; SMN2KMT2APSEN1PSEN2APH1B | |
| SCHEMBL366806 | 0.81 | ALDH1A1 (0.35) | KMT2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL366016 | 0.81 | MAPK12 (0.39) | SMN1; SMN2TSHRLMNAHTT | |
| SCHEMBL367225 | 0.80 | KMT2A (0.40) | SMN1; SMN2KMT2APSEN1PSEN2APH1B | |
| SCHEMBL365786 | 0.79 | ALDH1A1 (0.38) | KMT2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL367249 | 0.78 | MEN1 (0.36) | KMT2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL365965 | 0.77 | ACVR2A (0.38) | TSHRLMNAHTTHTR1A | |
| SCHEMBL366567 | 0.76 | PSEN1 (0.38) | MCL1SMN1; SMN2KMT2APSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |