Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365106 | 0.90 | KMT2A (0.39) | KMT2ASMN1; SMN2MAPTLMNATSHR | |
| SCHEMBL366567 | 0.87 | PSEN1 (0.38) | KMT2ASMN1; SMN2MAPTTSHRMAPK1 | |
| SCHEMBL364641 | 0.86 | PLK1 (0.38) | KMT2ASMN1; SMN2MAPTPSEN1PSEN2 | |
| SCHEMBL365965 | 0.82 | ACVR2A (0.38) | LMNATSHRHTTKDM4E | |
| SCHEMBL365786 | 0.82 | ALDH1A1 (0.38) | KMT2AMAPTLMNAHTTPSEN1 | |
| SCHEMBL367249 | 0.81 | MEN1 (0.36) | KMT2AMAPTLMNAHTTPSEN1 | |
| SCHEMBL366016 | 0.81 | MAPK12 (0.39) | SMN1; SMN2LMNATSHRHTTKDM4E | |
| SCHEMBL366807 | 0.80 | MCL1 (0.33) | KMT2ASMN1; SMN2MAPTLMNATSHR | |
| SCHEMBL366032 | 0.80 | PSEN1 (0.38) | KMT2ASMN1; SMN2MAPTLMNAHTT | |
| SCHEMBL365490 | 0.80 | NCEH1 (0.39) | KMT2ASMN1; SMN2TSHRMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |