Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | SNCA | P37840 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364643 | 0.92 | CYP11B1 (0.40) | MAPK12MAPK14CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL365965 | 0.92 | ACVR2A (0.38) | CYP1A2CYP3A4CYP2C9HTTKDM4E | |
| SCHEMBL364641 | 0.90 | PLK1 (0.38) | CNR2SMN1; SMN2CNR1 | |
| SCHEMBL366695 | 0.85 | MKNK1 (0.41) | MAPK12MAPK14CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL367249 | 0.85 | MEN1 (0.36) | HTTLMNA | |
| SCHEMBL365786 | 0.85 | ALDH1A1 (0.38) | HTTLMNA | |
| SCHEMBL367194 | 0.84 | GPR132 (0.38) | CYP1A2CYP3A4CYP2C9HTT | |
| SCHEMBL366073 | 0.83 | ALKBH1 (0.36) | CNR2KDM4ESMN1; SMN2CNR1 | |
| SCHEMBL366807 | 0.81 | MCL1 (0.33) | HTTTSHRLMNASMN1; SMN2 | |
| SCHEMBL367225 | 0.81 | KMT2A (0.40) | CNR2HTTKDM4ETSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |