Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ICMT | O60725 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL367347 | 0.92 | KMT2A (0.38) | MEN1USP2POLBKMT2AICMT | |
| SCHEMBL365786 | 0.92 | ALDH1A1 (0.38) | MEN1POLBKMT2ALMNAMAPT | |
| SCHEMBL364641 | 0.90 | PLK1 (0.38) | POLBKMT2AMAPTPSEN1PSEN2 | |
| SCHEMBL365925 | 0.86 | ACHE (0.42) | ICMT | |
| SCHEMBL366915 | 0.85 | PSEN1 (0.37) | MEN1USP2POLBKMT2ALMNA | |
| SCHEMBL366016 | 0.85 | MAPK12 (0.39) | LMNAHTT | |
| SCHEMBL366565 | 0.84 | ALDH1A1 (0.39) | MEN1POLBKMT2AMAPTPSEN1 | |
| SCHEMBL366073 | 0.83 | ALKBH1 (0.36) | MEN1POLBKMT2AMAPTPSEN1 | |
| SCHEMBL367248 | 0.81 | ALDH1A1 (0.37) | MEN1POLBKMT2AICMTLMNA | |
| SCHEMBL367225 | 0.81 | KMT2A (0.40) | MEN1KMT2ALMNAMAPTPSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |