Mesotrione

Mesotrione

SCHEMBL366882

CC(N)=O.CS(=O)(=O)c1ccc(C(=O)C2C(=O)CCCC2=O)c([N+](=O)[O-])c1

nearest known ligand 0.91

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HPD P32754 1/20 0.58
ALDH3A1 P30838 3/20 0.42
ALDH1A1 P00352 2/20 0.40
LMNA P02545 1/20 0.40
GAA P10253 1/20 0.40
MAPT P10636 1/20 0.40
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Mesotrione SCHEMBL4895947 0.95 HPD (0.62) HPDALDH3A1ALDH1A1LMNAGAA
Mesotrione SCHEMBL22116 0.95 HPD (0.62) HPDALDH3A1ALDH1A1LMNAGAA
Mesotrione SCHEMBL29352201 0.95 HPD (0.62) HPDALDH3A1ALDH1A1LMNAGAA
Mesotrione SCHEMBL2503425 0.94 HPD (0.61) HPDALDH3A1ALDH1A1LMNAGAA
Mesotrione SCHEMBL20723476 0.94 HPD (0.61) HPDALDH3A1ALDH1A1LMNAGAA
Mesotrione SCHEMBL1667345 0.94 HPD (0.61) HPDALDH3A1ALDH1A1LMNAGAA
Mesotrione SCHEMBL1162075 0.94 HPD (0.61) HPDALDH3A1ALDH1A1LMNAGAA
Mesotrione SCHEMBL2233142 0.94 HPD (0.61) HPDALDH3A1ALDH1A1LMNAGAA
Mesotrione SCHEMBL22720520 0.93 HPD (0.60) HPDALDH3A1ALDH1A1LMNAGAA
Mesotrione SCHEMBL19838155 0.92 HPD (0.57) HPDALDH3A1ALDH1A1LMNAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1531670-B1 HERBICIDAL COMPOSITION SYNGENTA PARTICIPATIONS AG (CH) 2015-12-09 EP disclosed
US-8551918-B2 Herbicidal composition SYNGENTA CROP PROTECTION LLC (US) 2013-10-08 US disclosed
US-8097561-B2 Herbicidal composition SYNGENTA CROP PROTECTION, INC. (US) 2012-01-17 US disclosed
US-20070197387-A1 Herbicidal Composition SYNGENTA PARTICIPATIONS AG (CH) 2007-08-23 US disclosed
EP-1689227-A2 HERBICIDAL COMPOSITION Syngenta Participations AG (CH) 2006-08-16 EP disclosed
EP-1531670-A4 HERBICIDAL COMPOSITION SYNGENTA PARTICIPATIONS AG (CH) 2005-11-23 EP disclosed
US-20050233907-A1 Herbicidal composition SYNGENTA CROP PROTECTION AG (CH) 2005-10-20 US disclosed
WO-2005055716-A2 HERBICIDAL COMPOSITION SYNGENTA PARTICIPATIONS AG (CH) 2005-06-23 WO disclosed
EP-1531670-A1 HERBICIDAL COMPOSITION Syngenta Participations AG (CH) 2005-05-25 EP disclosed
WO-2003105587-A1 HERBICIDAL COMPOSITION SYNGENTA PARTICIPATIONS AG (CH) 2003-12-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050233907-A1 Herbicidal composition ADH5, ADH1C, AQP3 HPD 405/4885ALDH3A1 28/4885ALDH1A1 81/4885
US-20070197387-A1 Herbicidal Composition DDT, HDHD5, DERL1 HPD 29/4885ALDH3A1 1884/4885ALDH1A1 1746/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.