Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTHFD2 | P13995 | 7/20 | 0.42 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SPR | P35270 | 3/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1622336 | 0.86 | SPR (0.44) | MTHFD2TNKS2SPR | |
| SCHEMBL1623370 | 0.82 | CLPP (0.51) | — | |
| SCHEMBL23972347 | 0.77 | ROCK2 (0.43) | MTHFD2LMNA | |
| SCHEMBL23972348 | 0.76 | CLPP (0.47) | MTHFD2KMT2ALMNA | |
| SCHEMBL23972242 | 0.76 | HTR2C (0.47) | TNKSTNKS2HTR2C | |
| SCHEMBL21003097 | 0.75 | ADORA2A (0.41) | MTHFD2SPR | |
| SCHEMBL3675829 | 0.74 | PDE9A (0.45) | MTHFD2TNKS2LMNASPRHTR2C | |
| SCHEMBL3673639 | 0.72 | MTHFD2 (0.44) | MTHFD2DGAT2TNKSTNKS2KMT2A | |
| SCHEMBL3736686 | 0.69 | HTR2C (0.37) | LMNAHTR2C | |
| SCHEMBL3669330 | 0.67 | HTR2C (0.52) | TNKSTNKS2LMNAHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139896-A1 | PYRIMIDO [4, 5-D]AZEPINE DERIVATIVES AS 5-HT2C AGONISTS | Pfizer Limited (GB) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008117169-A1 | PYRIMIDO [4, 5-D] AZEPINE DERIVATIVES AS 5-HT2C AGONISTS | PFIZER LIMITED (GB) | 2008-10-02 | — | — | WO | disclosed |