Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL366811 | 0.91 | EGFR (0.44) | EGFRSRCNPC1FGFR1MAPT | |
| SCHEMBL365259 | 0.91 | KDM4E (0.44) | EGFRSRCHTR2AHTR2CCYP3A4 | |
| SCHEMBL367330 | 0.89 | EGFR (0.46) | EGFRSRCNPC1HTR2AHTR2C | |
| SCHEMBL365635 | 0.86 | IDO1 (0.44) | EGFRSRCNPC1HTR2AHTR2C | |
| SCHEMBL367201 | 0.84 | EGFR (0.45) | EGFRSRCHTR2AHTR2CPARP1 | |
| SCHEMBL365229 | 0.80 | HPGD (0.48) | POLBTSHRTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL364594 | 0.79 | EGFR (0.44) | EGFRSRCMAPTHSD17B10POLB | |
| SCHEMBL367707 | 0.79 | EGFR (0.44) | EGFRSRCHTR2AHTR2CSMN1; SMN2 | |
| SCHEMBL367705 | 0.79 | EGFR (0.48) | EGFRSRCNPC1HTR2AHTR2C | |
| SCHEMBL365935 | 0.79 | KDM4E (0.47) | EGFRSRCPOLBCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |