Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.48 |
| ▸ | SRC | P12931 | 5/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365779 | 0.87 | EGFR (0.43) | EGFRSRCALDH1A1POLBKDM4E | |
| SCHEMBL365370 | 0.83 | NPC1 (0.47) | EGFRSRCALDH1A1KDM4EMEN1 | |
| SCHEMBL367201 | 0.79 | EGFR (0.45) | EGFRSRCHTR2AHTR2CALDH1A1 | |
| SCHEMBL367764 | 0.79 | EGFR (0.45) | EGFRSRCHTR2AHTR2CALDH1A1 | |
| SCHEMBL367704 | 0.79 | EGFR (0.43) | EGFRSRCALDH1A1POLBKDM4E | |
| SCHEMBL367330 | 0.78 | EGFR (0.46) | EGFRSRCHTR2AHTR2CALDH1A1 | |
| SCHEMBL367707 | 0.77 | EGFR (0.44) | EGFRSRCHTR2AHTR2CMEN1 | |
| SCHEMBL364594 | 0.77 | EGFR (0.44) | EGFRSRCALDH1A1POLBKDM4E | |
| SCHEMBL365259 | 0.77 | KDM4E (0.44) | EGFRSRCHTR2AHTR2CALDH1A1 | |
| SCHEMBL367114 | 0.76 | ALDH1A1 (0.49) | EGFRSRCALDH1A1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |