Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 7/20 | 0.40 |
| ▸ | SRC | P12931 | 5/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL367705 | 0.87 | EGFR (0.48) | EGFRKDM4EALDH1A1POLBAGTR1 | |
| SCHEMBL365370 | 0.85 | NPC1 (0.47) | EGFRKDM4EALDH1A1SRCMEN1 | |
| SCHEMBL366888 | 0.78 | EGFR (0.44) | EGFRKDM4EALDH1A1POLBHPGD | |
| SCHEMBL365935 | 0.78 | KDM4E (0.47) | EGFRKDM4EALDH1A1POLBHPGD | |
| SCHEMBL365778 | 0.78 | EGFR (0.42) | EGFRKDM4EALDH1A1POLBHPGD | |
| SCHEMBL366876 | 0.78 | EGFR (0.44) | EGFRKDM4EALDH1A1POLBHPGD | |
| SCHEMBL367114 | 0.77 | ALDH1A1 (0.49) | EGFRALDH1A1POLBHPGDSRC | |
| SCHEMBL365014 | 0.77 | KDM4E (0.48) | EGFRKDM4EALDH1A1POLBHPGD | |
| SCHEMBL367747 | 0.75 | AGTR1 (0.48) | EGFRKDM4EALDH1A1POLBHPGD | |
| SCHEMBL366811 | 0.75 | EGFR (0.44) | EGFRKDM4EALDH1A1POLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |