Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | AHR | P35869 | 1/20 | 0.48 |
| ▸ | HMGCR | P04035 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15434035 | 0.88 | ALDH1A1 (0.75) | ALDH1A1SMN1; SMN2HTTHPGDMAPT | |
| SCHEMBL3676230 | 0.83 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2MAPTMAPK1MEN1 | |
| SCHEMBL21765855 | 0.77 | HTT (0.72) | ALDH1A1SMN1; SMN2HTTMAPTMAPK1 | |
| SCHEMBL2792741 | 0.77 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2HSP90AA1MAPTMAPK1 | |
| SCHEMBL28167755 | 0.76 | HMGCR (0.75) | ALDH1A1SMN1; SMN2HTTHPGDHSP90AA1 | |
| SCHEMBL21765858 | 0.76 | CYP3A4 (0.56) | ALDH1A1SMN1; SMN2HTTHPGDMAPT | |
| SCHEMBL11691270 | 0.75 | HTT (0.52) | ALDH1A1SMN1; SMN2HTTMAPTMAPK1 | |
| SCHEMBL3680301 | 0.74 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2HTTHPGDMAPT | |
| SCHEMBL3680300 | 0.74 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2HTTHPGDMAPT | |
| SCHEMBL3404609 | 0.74 | CYP3A4 (0.69) | ALDH1A1SMN1; SMN2HTTHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820771-B2 | copolymer of styrene, ethylvinylbenzene, divinylbenzene and trimethoxysilylpropyl(meth)acrylate, being in the form of nanobeads as reinforcing filler; tires or rubber semi-finished products intended for these tires | MICHELIN RECHERCHE ET TECHNIQUE S. A. (CH) | 2010-10-26 | — | — | US | disclosed |
| EP-1922074-B1 | A COMBINATION OF COMPOUNDS, WHICH CAN BE USED IN THE TREATMENT OF RESPIRATORY DISEASES, ESPECIALLY CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) AND ASTHMA. | ASTRAZENECA AB (SE) | 2010-02-17 | — | — | EP | disclosed |
| US-20090298875-A1 | A Combination of Compounds, Which Can be Used in the Treatment of Respiratory Diseases, Especially Chronic Obstructive Pulmonary Disease (COPD) and Asthma | ASTRAZENECA AB (SE) | 2009-12-03 | — | — | US | disclosed |
| US-20090215732-A1 | COMBINATION OF COMPOUNDS, WHICH CAN BE USED IN THE TREATMENT OF RESPIRATORY DISEASES, ESPECIALLY CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) AND ASTHMA | ASTRAZENECA AB (SE) | 2009-08-27 | — | — | US | disclosed |
| CN-101296701-A | A combination of compounds, which can be used in the treatment of respiratory diseases, especially chronic obstructive pulmonary disease (COPD) and asthma | ASTRAZENECA AB (SE) | 2008-10-29 | — | — | CN | disclosed |
| CN-101296698-A | Combination of compounds for the treatment of respiratory diseases, in particular Chronic Obstructive Pulmonary Disease (COPD) and asthma | ASTRAZENECA AB (SE) | 2008-10-29 | — | — | CN | disclosed |
| US-20080194632-A1 | Novel Piperidine Derivatives as Chemokine Receptor Modulators Useful for the Treatment of Respiratory Diseases | ASTRAZENECA AB (SE) | 2008-08-14 | — | — | US | disclosed |
| US-20080132644-A1 | copolymer of styrene, ethylvinylbenzene, divinylbenzene and trimethoxysilylpropyl(meth)acrylate, being in the form of nanobeads as reinforcing filler; tires or rubber semi-finished products intended for these tires | MICHELIN RECHERCHE ET TECHNIQUE S.A. (CH) | 2008-06-05 | — | — | US | disclosed |
| EP-1922070-A1 | A COMBINATION OF COMPOUNDS, WHICH CAN BE USED IN THE TREATMENT OF RESPIRATORY DISEASES, ESPECIALLY CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) AND ASTHMA | AstraZeneca AB (SE) | 2008-05-21 | — | — | EP | disclosed |
| EP-1922074-A1 | A COMBINATION OF COMPOUNDS, WHICH CAN BE USED IN THE TREATMENT OF RESPIRATORY DISEASES, ESPECIALLY CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) AND ASTHMA. | AstraZeneca AB (SE) | 2008-05-21 | — | — | EP | disclosed |
| WO-2007024182-A1 | A COMBINATION OF COMPOUNDS, WHICH CAN BE USED IN THE TREATMENT OF RESPIRATORY DISEASES, ESPECIALLY CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) AND ASTHMA. | ASTRAZENECA AB (SE) | 2007-03-01 | — | — | WO | disclosed |
| WO-2007024183-A1 | A COMBINATION OF COMPOUNDS, WHICH CAN BE USED IN THE TREATMENT OF RESPIRATORY DISEASES, ESPECIALLY CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) AND ASTHMA | ASTRAZENECA AB (SE) | 2007-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215732-A1 | COMBINATION OF COMPOUNDS, WHICH CAN BE USED IN THE TREATMENT OF RESPIRATORY DISEASES, ESPECIALLY CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) AND ASTHMA | NR3C1, NR3C2, CHRM3 | ALDH1A1 876/4885SMN1; SMN2 3812/4885HTT 4774/4885 |
| US-20080194632-A1 | Novel Piperidine Derivatives as Chemokine Receptor Modulators Useful for the Treatment of Respiratory Diseases | ACKR3, CCR5, CCR2 | ALDH1A1 809/4885SMN1; SMN2 3256/4885HTT 4184/4885 |
| US-20090298875-A1 | A Combination of Compounds, Which Can be Used in the Treatment of Respiratory Diseases, Especially Chronic Obstructive Pulmonary Disease (COPD) and Asthma | ADRB2, ADRB1, CHRM2 | ALDH1A1 1195/4885SMN1; SMN2 2762/4885HTT 4745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.