Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH3 | Q9ULD8 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 2/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3787051 | 0.87 | MEN1 (0.39) | KCNH3MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL3781206 | 0.83 | CNR2 (0.36) | MEN1KMT2ASMN1; SMN2LMNANPC1 | |
| SCHEMBL3788039 | 0.82 | MAPT (0.44) | KCNH3MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL3706380 | 0.79 | KCNH3 (0.42) | KCNH3SCN9A | |
| SCHEMBL3785711 | 0.79 | KCNH3 (0.43) | KCNH3MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL3780588 | 0.78 | LMNA (0.42) | KCNH3MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL3785163 | 0.73 | KCNH3 (0.40) | KCNH3MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL3776179 | 0.72 | MPO (0.39) | MEN1KMT2ASMN1; SMN2LMNANPC1 | |
| SCHEMBL3779747 | 0.71 | MPO (0.38) | MEN1KMT2ASMN1; SMN2LMNANPC1 | |
| SCHEMBL3787119 | 0.71 | KCNH3 (0.39) | KCNH3MEN1KMT2ALMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010083645-A1 | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF | SHANGHAI TARGETDRUG CO., LTD (CN) | 2010-07-29 | — | — | WO | disclosed |