Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 7/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6908682 | 0.98 | HSD11B1 (0.50) | HSD11B1TSHRGAAHSD17B10ALDH1A1 | |
| SCHEMBL6913965 | 0.95 | HSD11B1 (0.48) | HSD11B1TSHRGAAHSD17B10ALDH1A1 | |
| SCHEMBL1421724 | 0.95 | HSD11B1 (0.48) | HSD11B1TSHRGAAHSD17B10ALDH1A1 | |
| Lithium Ion SCHEMBL3709427 | 0.95 | HSD11B1 (0.48) | HSD11B1TSHRGAAHSD17B10ALDH1A1 | |
| SCHEMBL6913303 | 0.95 | HSD11B1 (0.48) | HSD11B1TSHRGAAHSD17B10ALDH1A1 | |
| Zinc Ion SCHEMBL6917689 | 0.95 | HSD11B1 (0.48) | HSD11B1TSHRGAAHSD17B10ALDH1A1 | |
| SCHEMBL6909483 | 0.95 | HSD11B1 (0.48) | HSD11B1TSHRGAAHSD17B10ALDH1A1 | |
| SCHEMBL6247405 | 0.95 | HSD11B1 (0.50) | HSD11B1TSHRGAAHSD17B10ALDH1A1 | |
| SCHEMBL6912706 | 0.95 | HSD11B1 (0.48) | HSD11B1TSHRGAAHSD17B10ALDH1A1 | |
| SCHEMBL6918636 | 0.95 | HSD11B1 (0.48) | HSD11B1TSHRGAAHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675785-B1 | INDUSTRIAL METHODS FOR PRODUCING ARYLSULFUR PENTAFLUORIDES | UBE INDUSTRIES (JP) | 2018-04-11 | — | — | EP | disclosed |
| US-9676710-B2 | Industrial methods for producing arylsulfur pentafluorides | UBE INDUSTRIES, LTD. (JP) | 2017-06-13 | — | — | US | disclosed |
| US-9630920-B2 | Industrial methods for producing arylsulfur pentafluorides | UBE INDUSTRIES, LTD. (JP) | 2017-04-25 | — | — | US | disclosed |
| US-9630919-B2 | Industrial methods for producing arylsulfur pentafluorides | UBE INDUSTRIES, LTD. (JP) | 2017-04-25 | — | — | US | disclosed |
| EP-2460789-B1 | METHOD FOR PRODUCING BIARYL COMPOUND | SUMITOMO CHEMICAL CO (JP) | 2017-04-19 | — | — | EP | disclosed |
| US-20160362366-A1 | Industrial Methods for Producing Arylsulfur Pentafluorides | UBE CORPORATION (JP) | 2016-12-15 | — | — | US | disclosed |
| US-20160362367-A1 | Industrial Methods for Producing Arylsulfur Pentafluorides | UBE CORPORATION (JP) | 2016-12-15 | — | — | US | disclosed |
| US-20160362365-A1 | Industrial Methods for Producing Arylsulfur Pentafluorides | UBE CORPORATION (JP) | 2016-12-15 | — | — | US | disclosed |
| US-9447034-B2 | Industrial methods for producing arylsulfur pentafluorides | UBE INDUSTRIES, LTD. (JP) | 2016-09-20 | — | — | US | disclosed |
| US-20150315139-A1 | Industrial Methods for Producing Arylsulfur Pentafluorides | UBE CORPORATION (JP) | 2015-11-05 | — | — | US | disclosed |
| US-9108910-B2 | Industrial methods for producing arylsulfur pentafluorides | UBE INDUSTRIES, LTD. (JP) | 2015-08-18 | — | — | US | disclosed |
| US-9079830-B2 | Method for producing biaryl compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2015-07-14 | — | — | US | disclosed |
| EP-2675785-A1 | INDUSTRIAL METHODS FOR PRODUCING ARYLSULFUR PENTAFLUORIDES | Ube Industries, Ltd. (JP) | 2013-12-25 | — | — | EP | disclosed |
| US-20130324765-A1 | Industrial Methods for Producing Arylsulfur Pentafluorides | UBE INDUSTRIES, LTD. (JP) | 2013-12-05 | — | — | US | disclosed |
| WO-2012111839-A1 | INDUSTRIAL METHODS FOR PRODUCING ARYLSULFUR PENTAFLUORIDES | UBE INDUSTRIES, LTD. (JP) | 2012-08-23 | — | — | WO | disclosed |
| EP-2460789-A1 | METHOD FOR PRODUCING BIARYL COMPOUND | Sumitomo Chemical Company, Limited (JP) | 2012-06-06 | — | — | EP | disclosed |
| US-20120123154-A1 | METHOD FOR PRODUCING BIARYL COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-05-17 | — | — | US | disclosed |
| US-4104253-A | HALOGENATED ORGANIC ALKALI OR ALKALINE EARTH METAL SALTS | GENERAL ELECTRIC COMPANY (US) | 1978-08-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130324765-A1 | Industrial Methods for Producing Arylsulfur Pentafluorides | PFAS, ARSA, CYP2F1 | HSD11B1 426/4885TSHR 198/4885GAA 840/4885 |
| US-20150315139-A1 | Industrial Methods for Producing Arylsulfur Pentafluorides | PFAS, ARSA, CYP2F1 | HSD11B1 426/4885TSHR 198/4885GAA 840/4885 |
| US-20160362367-A1 | Industrial Methods for Producing Arylsulfur Pentafluorides | PFAS, ARSA, CYP2F1 | HSD11B1 426/4885TSHR 198/4885GAA 840/4885 |
| US-20160362365-A1 | Industrial Methods for Producing Arylsulfur Pentafluorides | PFAS, ARSA, CYP2F1 | HSD11B1 426/4885TSHR 198/4885GAA 840/4885 |
| US-20160362366-A1 | Industrial Methods for Producing Arylsulfur Pentafluorides | PFAS, ARSA, CYP2F1 | HSD11B1 426/4885TSHR 198/4885GAA 840/4885 |
| US-20120123154-A1 | METHOD FOR PRODUCING BIARYL COMPOUND | AKR7A2, AOC2, CBR1 | HSD11B1 119/4885TSHR 1160/4885GAA 1436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.