Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3711117 | 0.90 | TSHR (0.43) | TSHRLPAR1LMNAUSP2LPAR5 | |
| SCHEMBL3705439 | 0.88 | TSPO (0.38) | TSHRLMNAUSP2THRBTHRA | |
| SCHEMBL3710069 | 0.87 | POLB (0.47) | TSHRLPAR1MEN1KMT2AF2 | |
| SCHEMBL3704908 | 0.87 | MAPT (0.39) | LPAR1LMNAUSP2LPAR5THRB | |
| SCHEMBL3704670 | 0.86 | TSHR (0.40) | TSHRLPAR1THRBMEN1KMT2A | |
| SCHEMBL3704933 | 0.86 | NR3C1 (0.38) | TSHRLPAR1LMNAUSP2LPAR5 | |
| SCHEMBL3703153 | 0.85 | THRB (0.45) | THRBTHRA | |
| SCHEMBL3707230 | 0.85 | LMNA (0.36) | TSHRLPAR1LMNAUSP2THRB | |
| SCHEMBL3714771 | 0.84 | ESR1 (0.38) | TSHRLPAR1LMNAUSP2THRB | |
| SCHEMBL3711114 | 0.84 | TSHR (0.44) | TSHRLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | claimed |
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | disclosed |