Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 5/20 | 0.44 |
| ▸ | HTR6 | P50406 | 5/20 | 0.44 |
| ▸ | BCHE | P06276 | 4/20 | 0.44 |
| ▸ | ACHE | P22303 | 3/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR1E | P28566 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714049 | 0.90 | HRH1 (0.55) | KDM4EALDH1A1HRH1HTR6BCHE | |
| SCHEMBL4689854 | 0.73 | KDM4E (0.57) | KDM4EALDH1A1HRH1HTR6BCHE | |
| SCHEMBL12196034 | 0.73 | KDM4E (0.75) | KDM4EALDH1A1HRH1HTR6BCHE | |
| Hydrochloric Acid SCHEMBL4123600 | 0.73 | KDM4E (0.56) | KDM4EALDH1A1HRH1HTR6BCHE | |
| SCHEMBL13833905 | 0.72 | KDM4E (0.60) | KDM4EALDH1A1HRH1HTR6BCHE | |
| SCHEMBL2810779 | 0.71 | SIGMAR1 (0.54) | KDM4EALDH1A1HRH1HTR6BCHE | |
| SCHEMBL15119420 | 0.71 | SIGMAR1 (0.54) | KDM4EALDH1A1HRH1HTR6BCHE | |
| SCHEMBL13394801 | 0.71 | SIGMAR1 (0.54) | KDM4EALDH1A1HRH1HTR6BCHE | |
| SCHEMBL1662164 | 0.70 | ALDH1A1 (1.00) | KDM4EALDH1A1HRH1HTR6BCHE | |
| SCHEMBL30945675 | 0.70 | ALDH1A1 (1.00) | KDM4EALDH1A1HRH1HTR6BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100120792-A1 | Substituted 2,3,4,5-Tetrahyrdo-1H-Pyrido[4,3-B]Indoles, Methods for the Production and Use Thereof | ALLA CHEM, LLC | 2010-05-13 | — | — | US | claimed |
| US-20190233409-A1 | SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLES, METHODS FOR USE THEREOF | IVACHTCHENKO ALEXANDRE VASILIEVICH (US) | 2019-08-01 | — | — | US | disclosed |
| US-9655886-B2 | Substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles, methods for use thereof | IVACHTCHENKO ALEXANDRE VASILIEVICH (US) | 2017-05-23 | — | — | US | disclosed |
| US-20170000773-A1 | SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLES, METHODS FOR USE THEREOF | IVACHTCHENKO ALEXANDRE VASILIEVICH (US) | 2017-01-05 | — | — | US | disclosed |
| US-8541437-B2 | Substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles, methods for the production and use thereof | ALLA CHEM, LLC (US) | 2013-09-24 | — | — | US | disclosed |
| US-20130217703-A1 | SUSTITUTED 2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLES, METHODS FOR USE THEREOF | ALLA CHEM, LLC (US) | 2013-08-22 | — | — | US | disclosed |
| US-20100120792-A1 | Substituted 2,3,4,5-Tetrahyrdo-1H-Pyrido[4,3-B]Indoles, Methods for the Production and Use Thereof | ALLA CHEM, LLC | 2010-05-13 | — | — | US | disclosed |
| EP-2145887-A2 | SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLES, METHODS FOR THE PRODUCTION AND USE THEREOF | Alla Chem, LLC. (US) | 2010-01-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120792-A1 | Substituted 2,3,4,5-Tetrahyrdo-1H-Pyrido[4,3-B]Indoles, Methods for the Production and Use Thereof | HTR3C, HTR3A, HTR6 | KDM4E 4130/4885ALDH1A1 2039/4885HRH1 75/4885 |
| US-20190233409-A1 | SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLES, METHODS FOR USE THEREOF | ADORA3, HTR3C, TRPV3 | KDM4E 3153/4885ALDH1A1 1525/4885HRH1 139/4885 |
| US-20170000773-A1 | SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLES, METHODS FOR USE THEREOF | HTR6, HTR3C, HTR3B | KDM4E 4105/4885ALDH1A1 1667/4885HRH1 145/4885 |
| US-20130217703-A1 | SUSTITUTED 2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLES, METHODS FOR USE THEREOF | HTR6, HTR3C, HTR3B | KDM4E 3802/4885ALDH1A1 1390/4885HRH1 397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.