SCHEMBL3704908

SCHEMBL3704908

CCOC(=O)CN(C(=O)c1ccccc1)c1cc(Br)c(Oc2ccc(OC)c(C(=O)c3ccc(F)cc3)c2)c(Br)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.39
HTT P42858 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
ALDH1A1 P00352 1/20 0.39
HPGD P15428 2/20 0.37
THRA P10827 2/20 0.37
THRB P10828 2/20 0.37
CYP1A2 P05177 1/20 0.37
CYP2D6 P10635 1/20 0.37
CYP2C19 P33261 1/20 0.37
USP2 O75604 1/20 0.36
POLB P06746 2/20 0.36
LPAR1 Q92633 2/20 0.35
LPAR5 Q9H1C0 2/20 0.35
F2 P00734 1/20 0.35
F10 P00742 1/20 0.35
ITGB3 P05106 1/20 0.35
ITGA2B P08514 1/20 0.35
LMNA P02545 2/20 0.35
NR3C1 P04150 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3704933 0.93 NR3C1 (0.38) MAPTHTTNPSR1ALDH1A1HPGD
SCHEMBL3710069 0.92 POLB (0.47) MAPTHTTNPSR1ALDH1A1HPGD
SCHEMBL3704670 0.88 TSHR (0.40) MAPTHTTNPSR1HPGDTHRB
SCHEMBL3715784 0.87 TSHR (0.39) MAPTHPGDTHRATHRBUSP2
SCHEMBL3705439 0.85 TSPO (0.38) MAPTHTTALDH1A1HPGDTHRA
SCHEMBL3714771 0.83 ESR1 (0.38) MAPTHTTALDH1A1HPGDTHRA
SCHEMBL3703153 0.82 THRB (0.45) THRATHRBNR3C1
SCHEMBL3707230 0.82 LMNA (0.36) MAPTHTTALDH1A1HPGDTHRA
SCHEMBL3705791 0.82 STAT3 (0.44) HPGDTHRATHRBF2F10
SCHEMBL3223086 0.82 POLB (0.50) MAPTHTTNPSR1ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010086878-A2 THYROID RECEPTOR MODULATORS CADILA HEALTHCARE LIMITED (IN) 2010-08-05 WO claimed
WO-2010086878-A2 THYROID RECEPTOR MODULATORS CADILA HEALTHCARE LIMITED (IN) 2010-08-05 WO disclosed