Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 3/20 | 0.31 |
| ▸ | CES1 | P23141 | 3/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | PRKCG | P05129 | 1/20 | 0.31 |
| ▸ | PRKCB | P05771 | 1/20 | 0.31 |
| ▸ | PRKCA | P17252 | 1/20 | 0.31 |
| ▸ | PRKCH | P24723 | 1/20 | 0.31 |
| ▸ | PRKCI | P41743 | 1/20 | 0.31 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.31 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.31 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17024432 | 0.84 | TSHR (0.46) | ACE2TSHRMAPTCHRM1AKR1A1 | |
| SCHEMBL18920279 | 0.81 | ACE2 (0.55) | ACE2TSHRALDH1A1LMNAMAPT | |
| SCHEMBL7758037 | 0.81 | ACE2 (0.55) | ACE2TSHRALDH1A1LMNAMAPT | |
| SCHEMBL26383297 | 0.79 | ACE2 (0.40) | ACE2TSHRALDH1A1LMNAFFAR4 | |
| SCHEMBL3629224 | 0.78 | ALDH1A1 (0.60) | ACE2TSHRALDH1A1MAPTFFAR4 | |
| SCHEMBL10452861 | 0.78 | ALDH1A1 (0.37) | ALDH1A1MAPTFFAR4FFAR1CES2 | |
| SCHEMBL19346277 | 0.78 | TSHR (0.37) | ACE2TSHRALDH1A1LMNAMAPT | |
| SCHEMBL10917263 | 0.77 | ALDH1A1 (0.36) | ALDH1A1FFAR4FFAR1CES2CES1 | |
| SCHEMBL3717342 | 0.77 | LMNA (0.45) | TSHRALDH1A1LMNAFFAR4FFAR1 | |
| SCHEMBL1457100 | 0.77 | ALDH1A1 (0.63) | ACE2TSHRALDH1A1MAPTFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160354342-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF ACID-RELATED GASTROINTESTINAL DISORDERS CONTAINING A DITHIOLANE COMPOUND AND A GASTRIC ACID SECRETION INHIBITOR. | SHAHID MUSLIM D (US) | 2016-12-08 | — | — | US | claimed |
| US-9457011-B2 | Compositions and methods for the treatment of acid-related gastrointestinal disorders containing a dithiolane compound and a gastric acid secretion inhibitor | SHAHID MUSLIM D (US) | 2016-10-04 | — | — | US | claimed |
| US-20150238463-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF ACID-RELATED GASTROINTESTINAL DISORDERS CONTAINING A DITHIOLANE COMPOUND AND A GASTRIC ACID SECRETION INHIBITOR | SHAHID MUSLIM D (US) | 2015-08-27 | — | — | US | claimed |
| US-11426381-B2 | Lipoic acid choline ester compositions and methods of use | NOVARTIS AG (CH) | 2022-08-30 | — | — | US | disclosed |
| US-11273145-B2 | Compositions and methods for the treatment of acid-related gastrointestinal disorders containing a dithiolane compound and a gastric acid secretion inhibitor | SHAHID MUSLIM D (US) | 2022-03-15 | — | — | US | disclosed |
| US-20200281891-A1 | LIPOIC ACID CHOLINE ESTER COMPOSITIONS AND METHODS OF USE | ENCORE VISION, INC. | 2020-09-10 | — | — | US | disclosed |
| EP-3113613-A1 | LIPOIC ACID CHOLINE ESTER COMPOSITIONS AND METHODS OF USE | ENCORE VISION, INC. (US) | 2017-01-11 | — | — | EP | disclosed |
| US-20160354340-A1 | LIPOIC ACID CHOLINE ESTER COMPOSITIONS AND METHODS OF USE | NOVARTIS AG (CH) | 2016-12-08 | — | — | US | disclosed |
| US-20160354342-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF ACID-RELATED GASTROINTESTINAL DISORDERS CONTAINING A DITHIOLANE COMPOUND AND A GASTRIC ACID SECRETION INHIBITOR. | SHAHID MUSLIM D (US) | 2016-12-08 | — | — | US | disclosed |
| US-9457011-B2 | Compositions and methods for the treatment of acid-related gastrointestinal disorders containing a dithiolane compound and a gastric acid secretion inhibitor | SHAHID MUSLIM D (US) | 2016-10-04 | — | — | US | disclosed |
| WO-2015134510-A1 | LIPOIC ACID CHOLINE ESTER COMPOSITIONS AND METHODS OF USE | ENCORE VISION INC. (US) | 2015-09-11 | — | — | WO | disclosed |
| US-20150238463-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF ACID-RELATED GASTROINTESTINAL DISORDERS CONTAINING A DITHIOLANE COMPOUND AND A GASTRIC ACID SECRETION INHIBITOR | SHAHID MUSLIM D (US) | 2015-08-27 | — | — | US | disclosed |
| WO-2010110771-A2 | SUBSTITUTED THIOL-CONTAINING ALKYL FATTY ACIDS AND PROCESS FOR SYNTHESIZING DERIVATIVES THEREOF | GIBSON FRANK (US) | 2010-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11273145-B2 | Compositions and methods for the treatment of acid-related gastrointestinal disorders containing a dithiolane compound and a gastric acid secretion inhibitor | ALAD, FABP6, ALOX15B | ACE2 1648/4885TSHR 1529/4885ALDH1A1 848/4885 |
| US-20160354340-A1 | LIPOIC ACID CHOLINE ESTER COMPOSITIONS AND METHODS OF USE | LIPA, LIPC, PCYT1A | ACE2 4100/4885TSHR 3450/4885ALDH1A1 1082/4885 |
| US-20150238463-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF ACID-RELATED GASTROINTESTINAL DISORDERS CONTAINING A DITHIOLANE COMPOUND AND A GASTRIC ACID SECRETION INHIBITOR | FABP6, ALAD, SLC10A2 | ACE2 1482/4885TSHR 1544/4885ALDH1A1 906/4885 |
| US-20160354342-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF ACID-RELATED GASTROINTESTINAL DISORDERS CONTAINING A DITHIOLANE COMPOUND AND A GASTRIC ACID SECRETION INHIBITOR. | ALAD, ALOX15B, FABP6 | ACE2 1894/4885TSHR 1716/4885ALDH1A1 692/4885 |
| US-11426381-B2 | Lipoic acid choline ester compositions and methods of use | LIPA, LIPC, PCYT1A | ACE2 4100/4885TSHR 3450/4885ALDH1A1 1082/4885 |
| US-20200281891-A1 | LIPOIC ACID CHOLINE ESTER COMPOSITIONS AND METHODS OF USE | LIPA, LIPC, PCYT1A | ACE2 4100/4885TSHR 3450/4885ALDH1A1 1082/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.