Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 11/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10973419 | 0.84 | LMNA (0.52) | HTTLMNARAB9AMAPTALDH1A1 | |
| SCHEMBL3722747 | 0.79 | HTT (0.47) | HTTLMNARAB9AMAPTALDH1A1 | |
| SCHEMBL3720887 | 0.79 | HTT (0.47) | HTTLMNARAB9AMAPTALDH1A1 | |
| SCHEMBL3563953 | 0.78 | RAB9A (0.52) | HTTLMNARAB9AMAPTALDH1A1 | |
| SCHEMBL30891215 | 0.78 | RAB9A (0.52) | HTTLMNARAB9AMAPTALDH1A1 | |
| SCHEMBL3719822 | 0.77 | ALDH1A1 (0.51) | HTTLMNARAB9AMAPTALDH1A1 | |
| SCHEMBL3724731 | 0.77 | ALDH1A1 (0.47) | HTTLMNARAB9AMAPTALDH1A1 | |
| SCHEMBL3719825 | 0.76 | ALDH1A1 (0.45) | HTTLMNARAB9AMAPTALDH1A1 | |
| SCHEMBL4778707 | 0.72 | KMT2A (0.67) | HTTLMNARAB9AMAPTALDH1A1 | |
| SCHEMBL22926878 | 0.71 | TTR (0.47) | HTTLMNAMAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127208-A1 | INHIBITORS OF ACETYL-COA CARBOXYLASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-04 | — | — | WO | disclosed |