Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 1/20 | 0.38 |
| ▸ | POLG | P54098 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | POLA1 | P09884 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3721701 | 0.82 | KDM4E (0.46) | PNPPOLGPOLBPOLA1 | |
| SCHEMBL851106 | 0.76 | KDM4E (0.32) | — | |
| SCHEMBL381156 | 0.74 | — | — | |
| SCHEMBL9152040 | 0.71 | DHFR (0.40) | — | |
| SCHEMBL7077081 | 0.69 | KDM4E (0.33) | — | |
| Pyrophosphoric Acid SCHEMBL2935409 | 0.66 | KDM4E (0.49) | PNPPOLGPOLBPOLA1 | |
| SCHEMBL4619963 | 0.63 | P2RX3 (0.35) | — | |
| SCHEMBL4315532 | 0.61 | NOS1 (0.58) | PNPPOLGPOLBPOLA1 | |
| SCHEMBL381157 | 0.60 | — | — | |
| Pterine SCHEMBL2411220 | 0.58 | PNP (0.51) | PNPPOLGPOLBPOLA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060088900-A1 | Method for determining inhibition activity of a compound on one of the enzymes of the folate synthesis pathway | AVENTIS PHARMA S.A. (FR) | 2006-04-27 | — | — | US | claimed |
| EP-1281769-A1 | Screening-method for inhibitors of folate-synthesis-pathway enzymes | Aventis Pharma S.A. (FR) | 2003-02-05 | — | — | EP | claimed |
| US-12421187-B2 | Dihydrofolate synthase (DHFS) inhibiting agents and methods of making and using same | WASHINGTON UNIVERISTY (US) | 2025-09-23 | — | — | US | disclosed |
| CN-114286858-B | Folic acid producing strain, and preparation and application thereof | 赤峰制药股份有限公司 | 2024-05-28 | — | — | CN | disclosed |
| US-20230322667-A1 | DIHYDROFOLATE SYNTHASE (DHFS) INHIBITING AGENTS AND METHODS OF MAKING AND USING SAME | WASHINGTON UNIVERSITY (US) | 2023-10-12 | — | — | US | disclosed |
| US-20230272442-A1 | 5-METHYLFOLATE PRODUCING MICROORGANISM | CHIFENG PHARMACEUTICAL CO., LTD. (CN) | 2023-08-31 | — | — | US | disclosed |
| CN-116096881-A | Microorganism producing 5-methyl folate | 赤峰制药股份有限公司 | 2023-05-09 | — | — | CN | disclosed |
| US-20220282207-A1 | FOLATE PRODUCING STRAIN AND THE PREPARATION AND APPLICATION THEREOF | CHIFENG PHARMACEUTICAL CO., LTD. (CN) | 2022-09-08 | — | — | US | disclosed |
| CN-114286858-A | Folic acid producing strain and preparation and application thereof | 赤峰制药股份有限公司 | 2022-04-05 | — | — | CN | disclosed |
| WO-2022013663-A1 | 5-METHYLFOLATE PRODUCING MICROORGANISM | CHIFENG PHARMACEUTICAL CO., LTD. (CN) | 2022-01-20 | — | — | WO | disclosed |
| EP-3940071-A1 | 5-METHYLFOLATE PRODUCING MICROORGANISM | Chifeng Pharmaceutical Co., Ltd (CN) | 2022-01-19 | — | — | EP | disclosed |
| US-20040214261-A1 | Production of bioavailable folic acid | CAMPINA B.V. (NL) | 2004-10-28 | — | — | US | disclosed |
| EP-1414993-A2 | SCREENING-METHOD FOR INHIBITORS OF FOLATE-SYNTHESIS-PATHWAY ENZYMES | Aventis Pharma S.A. (FR) | 2004-05-06 | — | — | EP | disclosed |
| EP-1392816-A1 | PRODUCTION OF BIOAVAILABLE FOLIC ACID | Stichting Top-Instituut Voedselwetenschappen (NL) | 2004-03-03 | — | — | EP | disclosed |
| WO-2003104391-A2 | ANTIBACTERIAL TARGETS IN ALLOIOCOCCUS OTITIDIS | WYETH HOLDINGS CORPORATION (US) | 2003-12-18 | — | — | WO | disclosed |
| WO-2003012132-A2 | SCREENING METHOD FOR INHIBITORS OF FOLATE SYNTHESIS PATHWAY ENZYMES | AVENTIS PHARMA S.A. (FR) | 2003-02-13 | — | — | WO | disclosed |
| EP-1281769-A1 | Screening-method for inhibitors of folate-synthesis-pathway enzymes | Aventis Pharma S.A. (FR) | 2003-02-05 | — | — | EP | disclosed |
| WO-2002097063-A1 | PRODUCTION OF BIOAVAILABLE FOLIC ACID | CAMPINA B.V. (NL) | 2002-12-05 | — | — | WO | disclosed |
| EP-1262541-A1 | Production of bioavailable folic acid | Stichting Top-Instituut Voedselwetenschappen (NL) | 2002-12-04 | — | — | EP | disclosed |
| EP-0999284-A1 | Method for screening antimycotic substances using essential genes from c.albicans, and said genes | HOECHST MARION ROUSSEL (FR) | 2000-05-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230322667-A1 | DIHYDROFOLATE SYNTHASE (DHFS) INHIBITING AGENTS AND METHODS OF MAKING AND USING SAME | DHFR, DHPS, MTHFD1 | PNP 143/4885POLG 510/4885POLB 394/4885 |
| US-12421187-B2 | Dihydrofolate synthase (DHFS) inhibiting agents and methods of making and using same | DHFR, DHPS, MTHFD1 | PNP 143/4885POLG 510/4885POLB 394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.