SCHEMBL3726232

SCHEMBL3726232

O=C([O-])CCCNCc1cccnc1.[Na+]

nearest known ligand 0.63

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SYK known ✓ P43405 1/20 0.52
SCN8A known ✓ Q9UQD0 1/20 0.50
CHRM2 P08172 1/20 0.63
CYP1A2 P05177 2/20 0.56
CYP2D6 P10635 1/20 0.56
MAPT P10636 1/20 0.54
FES P07332 1/20 0.52
RET P07949 1/20 0.52
MARK3 P27448 1/20 0.52
TYK2 P29597 1/20 0.52
FLT4 P35916 1/20 0.52
CLK2 P49760 1/20 0.52
CLK4 Q9HAZ1 1/20 0.52
RECQL P46063 1/20 0.50
CYP3A4 P08684 2/20 0.48
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
ALDH1A1 P00352 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3722631 0.85 CHRM2 (0.67) CHRM2CYP1A2CYP2D6MAPTFES
SCHEMBL423358 0.82 CYP1A2 (0.62) CHRM2CYP1A2CYP2D6MAPTFES
SCHEMBL11594897 0.81 CHRM2 (0.93) CHRM2CYP1A2CYP2D6FESRET
SCHEMBL8641267 0.79 CYP1A2 (0.62) CHRM2CYP1A2CYP2D6MAPTFES
SCHEMBL9672546 0.79 CHRM2 (0.75) CHRM2CYP1A2CYP2D6MAPTFES
SCHEMBL14931588 0.78 CHRM2 (0.86) CHRM2CYP1A2CYP2D6FESRET
SCHEMBL19031318 0.78 CYP1A2 (0.83) CHRM2CYP1A2CYP2D6RECQLSCN8A
SCHEMBL29875178 0.78 CYP1A2 (0.83) CHRM2CYP1A2CYP2D6RECQLSCN8A
SCHEMBL29870183 0.76 CYP1A2 (0.74) CHRM2CYP1A2CYP2D6FESRET
SCHEMBL4051279 0.76 CYP1A2 (0.74) CHRM2CYP1A2CYP2D6FESRET

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100189819-A1 NEURO-DEGENERATIVE INHIBITOR, NEURO-ENDOCRINE MODULATOR, AND NEURO-CEREBRAL METABOLISM ENHANCER INTRATHERAPIES LLC (US) 2010-07-29 US disclosed
WO-2004032916-A1 A COMPOSITION COMPRISING SELEGELINE, PROCAINE, VINPOCETINE, TRIMETHYLGLYCINEAN AND A N-GABA INGREDIENT FOR TREATING NEURODEGENERATIVE DISORDERS UNIFUND CORPORATION LIMITED (GB) 2004-04-22 WO disclosed
US-20040067986-A1 Neuro-degenerative inhibitor, neuro-endocrine modulator, and neuro-cerebral metabolism enhancer UNIFUND CORPORATION 2004-04-08 US disclosed