Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 3/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.46 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 7/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 7/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 7/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 7/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 7/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 7/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3726618 | 0.84 | HTR6 (0.50) | NOS1NOS2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL9381846 | 0.84 | KDM1A (0.52) | NOS1KDM1ARCOR1NOS2ROCK2 | |
| SCHEMBL3597276 | 0.84 | CYP1A2 (0.56) | NOS1KDM1ARCOR1NOS2GRIN2D | |
| SCHEMBL7898720 | 0.81 | ITGB3 (0.43) | NOS1NOS2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL8269124 | 0.81 | SIGMAR1 (0.60) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL6679400 | 0.80 | KDM1A (0.44) | NOS1KDM1ARCOR1NOS2GRIN2D | |
| [3-(Hydroxymethyl)Phenyl]Guanidine SCHEMBL1186272 | 0.80 | PRSS1 (0.55) | NOS1KDM1ARCOR1NOS2GRIN2D | |
| SCHEMBL28347492 | 0.80 | ITGB3 (0.43) | NOS1NOS2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL6678310 | 0.80 | LOXL2 (0.55) | NOS1NOS2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL6679402 | 0.79 | SIGMAR1 (0.51) | NOS1NOS2GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435435-B1 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY | ABBVIE INC (US) | 2014-01-29 | — | — | EP | disclosed |
| US-8536180-B2 | Pyrimidine inhibitors of kinase activity | ABBVIE INC. (US) | 2013-09-17 | — | — | US | disclosed |
| CN-102459265-A | Pyrimidine inhibitors of kinase activity | ABBOTT LAB | 2012-05-16 | — | — | CN | disclosed |
| WO-2010138575-A1 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | WO | disclosed |
| US-20100305118-A1 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305118-A1 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY | IGF1R, TK1, CDK2 | NOS1 2688/4885KDM1A 2140/4885RCOR1 1088/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.