Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 12/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3733288 | 0.77 | L3MBTL1 (0.49) | P2RX7CES2CES1RIPK1 | |
| SCHEMBL3736155 | 0.77 | SIGMAR1 (0.46) | CES2CES1RIPK1 | |
| SCHEMBL6864273 | 0.77 | CES2 (0.46) | P2RX7CES2CES1RIPK1CA2 | |
| SCHEMBL243780 | 0.76 | ALDH1A1 (0.47) | — | |
| SCHEMBL892933 | 0.75 | CES2 (0.45) | P2RX7CES2CES1RIPK1CA2 | |
| SCHEMBL29459927 | 0.75 | CES2 (0.45) | P2RX7CES2CES1RIPK1CA2 | |
| SCHEMBL1474476 | 0.74 | F10 (0.43) | — | |
| SCHEMBL3734917 | 0.74 | DPP4 (0.38) | — | |
| SCHEMBL2151373 | 0.73 | CES2 (0.43) | P2RX7CES2CES1RIPK1CA2 | |
| SCHEMBL2870153 | 0.73 | RIPK1 (0.45) | P2RX7CES2CES1RIPK1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7829580-B2 | Cyclic amine derivative having heteroaryl ring | SANKYO COMPANY, LTD. (JP) | 2010-11-09 | — | — | US | disclosed |
| US-20060270706-A1 | Cyclic amine derivative having heteroaryl ring | SANKYO COMPANY, LTD. (JP) | 2006-11-30 | — | — | US | disclosed |
| EP-1695962-A1 | CYCLIC AMINE DERIVATIVE HAVING HETEROARYL RING | Sankyo Company, Limited (JP) | 2006-08-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060270706-A1 | Cyclic amine derivative having heteroaryl ring | F12, F2, H1-3 | P2RX7 61/4885CES2 346/4885CES1 177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.