Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29459927 | 1.00 | CES2 (0.45) | CES2CES1CXCL8AKR1B1RIPK1 | |
| SCHEMBL30517175 | 0.98 | CES2 (0.43) | CES2CES1CXCL8AKR1B1RIPK1 | |
| Methyl Alcohol SCHEMBL17241181 | 0.96 | RIPK1 (0.44) | CES2CES1CXCL8AKR1B1RIPK1 | |
| SCHEMBL6864273 | 0.84 | CES2 (0.46) | CES2CES1RIPK1CA2P2RX7 | |
| SCHEMBL31551958 | 0.84 | CES2 (0.39) | CES2CES1CXCL8RIPK1CA2 | |
| SCHEMBL25040843 | 0.83 | CXCL8 (0.42) | CES2CES1CXCL8AKR1B1P2RX7 | |
| SCHEMBL3150817 | 0.83 | AKR1B1 (0.45) | CES2CES1CXCL8AKR1B1CA2 | |
| SCHEMBL30759635 | 0.83 | CXCL8 (0.42) | CES2CES1CXCL8AKR1B1P2RX7 | |
| SCHEMBL31584219 | 0.83 | RXRA (0.44) | CES2CES1CXCL8AKR1B1RIPK1 | |
| SCHEMBL29009912 | 0.83 | RXRA (0.44) | CES2CES1CXCL8AKR1B1RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 262 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118290254-A | Rare earth complex for zinc battery electrolyte and preparation method and application thereof | 中国科学院赣江创新研究院 | 2024-07-05 | — | — | CN | claimed |
| US-20230048657-A1 | PROCESS FOR THE PREPARATION OF (9S)-2-BROMO-9-(2,3,4-TRIFLUOROPHENYL)-6,7,8,9-TETRAHYDRO-5H-[1,2,4]TRIAZOLO[1,5-A]AZEPINE | HOFFMANN-LA ROCHE INC. (US) | 2023-02-16 | — | — | US | claimed |
| EP-4065581-A1 | PROCESS FOR THE PREPARATION (9S)-2-BROMO-9-(2,3,4-TRIFLUOROPHENYL)-6,7,8,9-TETRAHYDRO-5H-[1,2,4]TRIAZOLO[1,5-A]AZEPINE | F. Hoffmann-La Roche AG (CH) | 2022-10-05 | — | — | EP | claimed |
| CN-114787163-A | Process for preparing (9S) -2-bromo-9- (2,3, 4-trifluorophenyl) -6,7,8, 9-tetrahydro-5H- [1,2,4] triazolo [1,5-a ] azepine | 豪夫迈·罗氏有限公司 | 2022-07-22 | — | — | CN | claimed |
| WO-2021105337-A1 | PROCESS FOR THE PREPARATION (9S)-2-BROMO-9-(2,3,4-TRIFLUOROPHENYL)-6,7,8,9-TETRAHYDRO-5H-[1,2,4]TRIAZOLO[1,5-A]AZEPINE | F. HOFFMANN-LA ROCHE AG (CH) | 2021-06-03 | — | — | WO | claimed |
| CN-107502412-B | High-temperature-resistant magnesium salt lubricating oil detergent and preparation method thereof | 黄山学院 | 2020-02-14 | — | — | CN | claimed |
| EP-3114715-B1 | P-DOPING CROSS-LINKING OF ORGANIC HOLE TRANSPORTERS | SIEMENS AG (DE) | 2019-10-30 | — | — | EP | claimed |
| EP-3114715-A1 | P-DOPING CROSS-LINKING OF ORGANIC HOLE TRANSPORTERS | Siemens Aktiengesellschaft (DE) | 2017-01-11 | — | — | EP | claimed |
| WO-2010122578-A2 | PROCESS FOR THE PREPARATION OF SITAGLIPTIN AND ITS INTERMEDIATES | MSN LABORATORIES LIMITED (IN) | 2010-10-28 | — | — | WO | claimed |
| US-6870067-B2 | Process for the synthesis of trifluorophenylacetic acids | MERCK & CO., INC. (US) | 2005-03-22 | — | — | US | claimed |
| US-20040077901-A1 | Process for the synthesis of trifluorophenylacetic acids | MERCK SHARP & DOHME LLC | 2004-04-22 | — | — | US | claimed |
| EP-4151620-B1 | METHOD FOR PREPARING CHIRAL 4-ARYL-BETA-AMINO ACID DERIVATIVE | ZHEJIANG MED XINCHANG PHARM (CN) | 2026-04-08 | — | — | EP | disclosed |
| US-12534427-B2 | Method for preparing chiral 4-aryl-β-amino acid derivative | ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY (CN) | 2026-01-27 | — | — | US | disclosed |
| US-12528828-B2 | Substituted pyrido[4,3-d]pyrimidines as KRAS modulators | ALTEROME THERAPEUTICS, INC. (US) | 2026-01-20 | — | — | US | disclosed |
| US-20250346610-A1 | SUBSTITUTED PYRIDO[4,3-d]PYRIMIDINES AS KRAS MODULATORS | ALTEROME THERAPEUTICS INC (US) | 2025-11-13 | — | — | US | disclosed |
| EP-0841063-A1 | KETONE DERIVATIVES AND MEDICINAL USE THEREOF | TORAY INDUSTRIES, INC. (JP) | 1998-05-13 | — | — | EP | disclosed |
| US-5744458-A | ANALGESICS | ADOLOR CORPORATION (US) | 1998-04-28 | — | — | US | disclosed |
| US-5688955-A | ANALGESICS | ADOLOR CORPORATION (US) | 1997-11-18 | — | — | US | disclosed |
| WO-1997032857-A1 | KAPPA AGONIST COMPOUNDS AND PHARMACEUTICAL FORMULATIONS THEREOF | ADOLOR CORPORATION (US) | 1997-09-12 | — | — | WO | disclosed |
| EP-0457243-A1 | Novel tricyclic compounds | SYNTEX (U.S.A.) INC. (US) | 1991-11-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230048657-A1 | PROCESS FOR THE PREPARATION OF (9S)-2-BROMO-9-(2,3,4-TRIFLUOROPHENYL)-6,7,8,9-TETRAHYDRO-5H-[1,2,4]TRIAZOLO[1,5-A]AZEPINE | APP, PSEN1, PSEN2 | CES2 1982/4885CES1 1767/4885CXCL8 921/4885 |
| US-12534427-B2 | Method for preparing chiral 4-aryl-β-amino acid derivative | OPRM1, SIGMAR1, GLRB | CES2 2328/4885CES1 2641/4885CXCL8 3346/4885 |
| US-20250346610-A1 | SUBSTITUTED PYRIDO[4,3-d]PYRIMIDINES AS KRAS MODULATORS | KRAS, NRAS, HRAS | CES2 4885/4885CES1 4334/4885CXCL8 4337/4885 |
| US-12528828-B2 | Substituted pyrido[4,3-d]pyrimidines as KRAS modulators | KRAS, NRAS, HRAS | CES2 4773/4885CES1 2321/4885CXCL8 3409/4885 |
| US-20040077901-A1 | Process for the synthesis of trifluorophenylacetic acids | GRHPR, PFAS, PCCA | CES2 1431/4885CES1 2759/4885CXCL8 4550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.