Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TSPO | P30536 | 1/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | GUSB | P08236 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9566567 | 0.74 | RAB9A (0.48) | — | |
| SCHEMBL18920567 | 0.74 | CYP1A2 (0.43) | LMNAJAK2CYP1A2CYP2A6TSHR | |
| SCHEMBL125432 | 0.73 | TSHR (0.39) | LMNAJAK2CYP1A2CYP2A6TSHR | |
| SCHEMBL20252178 | 0.73 | MEN1 (0.50) | LMNAJAK2CYP1A2CYP2A6MEN1 | |
| SCHEMBL31175951 | 0.70 | TDP1 (0.40) | LMNAJAK2CYP1A2CYP2A6TSHR | |
| SCHEMBL2471569 | 0.69 | TSHR (0.57) | LMNACYP1A2CYP2A6TSHRMEN1 | |
| SCHEMBL376122 | 0.68 | LMNA (0.73) | LMNAMEN1HTTKMT2ANOTUM | |
| SCHEMBL10455684 | 0.68 | TDP1 (0.46) | TDP1PSMB8 | |
| SCHEMBL4452908 | 0.66 | CYP1A2 (0.45) | LMNACYP1A2CYP2A6TSHRPDK2 | |
| SCHEMBL9782317 | 0.66 | L3MBTL1 (0.38) | LMNAJAK2CYP1A2TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102361556-B | Pyrimindine-4-ylpropane dinitrile derivatives, method for the production thereof, and use thereof as herbicide and plant growth regulators | BAYER CROPSCIENCE AG | 2015-02-18 | — | — | CN | disclosed |
| US-8309557-B2 | Pyrimidin-4-ylpropanedinitrile derivatives, processes for their preparation and their use as herbicides and plant growth regulators | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2012-11-13 | — | — | US | disclosed |
| EP-2408305-A1 | PYRIMINDINE-4-YLPROPANE DINITRILE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS HERBICIDE AND PLANT GROWTH REGULATORS | Bayer CropScience AG (DE) | 2012-01-25 | — | — | EP | disclosed |
| WO-2010108611-A1 | PYRIMINDINE-4-YLPROPANE DINITRILE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS HERBICIDE AND PLANT GROWTH REGULATORS | BAYER CROPSCIENCE AG (DE) | 2010-09-30 | — | — | WO | disclosed |
| US-20100240536-A1 | PYRIMIDIN-4-YLPROPANEDINITRILE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES AND PLANT GROWTH REGULATORS | BAYER CROPSCIENCE AG (DE) | 2010-09-23 | — | — | US | disclosed |
| EP-2229813-A1 | Pyrimidine-4-ylpropandinitrile derivatives, method for their manufacture and their use as herbicides and plant growth regulators | Bayer CropScience AG (DE) | 2010-09-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240536-A1 | PYRIMIDIN-4-YLPROPANEDINITRILE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES AND PLANT GROWTH REGULATORS | DDT, PLPBP, HPD | LMNA 3510/4885JAK2 2912/4885CYP1A2 218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.