Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Methylene Chloride. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylene Chloride SCHEMBL1392837 | 1.00 | — | — | |
| Methylene Chloride SCHEMBL237160 | 0.94 | — | — | |
| Methylene Chloride SCHEMBL4410896 | 0.94 | ALDH1A1 (0.44) | — | |
| Methylene Chloride SCHEMBL992285 | 0.94 | ALDH1A1 (0.57) | — | |
| Methylene Chloride SCHEMBL7090995 | 0.94 | ALDH1A1 (0.57) | — | |
| Methylene Chloride SCHEMBL3199266 | 0.94 | ALDH1A1 (0.57) | — | |
| Methylene Chloride SCHEMBL1832445 | 0.94 | ALDH1A1 (0.57) | — | |
| Methylene Chloride SCHEMBL9625167 | 0.94 | ALDH1A1 (0.57) | — | |
| Methylene Chloride SCHEMBL4784041 | 0.94 | ALDH1A1 (0.57) | — | |
| Methylene Chloride SCHEMBL948 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 877 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118255724-A | Synthesis method of lidocaine hydrochloride impurity and reaction detection method thereof | 河北天成药业股份有限公司 | 2024-06-28 | — | — | CN | claimed |
| CN-114920796-B | Steroid saponin compound extracted from paris polyphylla, preparation and application | 中国人民解放军空军军医大学 | 2024-05-07 | — | — | CN | claimed |
| CN-117890409-A | Method for identifying musk and musk ketone in musk preparation | 漳州片仔癀药业股份有限公司 | 2024-04-16 | — | — | CN | claimed |
| CN-117820509-A | Novel glycoside compounds of semen momordicae, preparation and application thereof | 上海交通大学 | 2024-04-05 | — | — | CN | claimed |
| CN-114805465-B | Triterpene compound, preparation method and application thereof | 沈阳药科大学 | 2024-04-02 | — | — | CN | claimed |
| CN-113730317-B | Method for extracting effective components for cosmetics from paris polyphylla | 浙江宜格企业管理集团有限公司 | 2024-03-26 | — | — | CN | claimed |
| CN-115677816-B | Novel furostanol saponin monomer and preparation method thereof | 吉林大学 | 2024-03-26 | — | — | CN | claimed |
| CN-117551086-A | Diterpene lactone derivative and preparation method thereof | 南通大学 | 2024-02-13 | — | — | CN | claimed |
| CN-117510571-A | Preparation method of sea cucumber alkane type saponin monomer | 吉林大学 | 2024-02-06 | — | — | CN | claimed |
| CN-117510568-A | Novel ginsenoside monomer and preparation method thereof | 吉林大学 | 2024-02-06 | — | — | CN | claimed |
| CN-101670088-A | Traditional Chinese medicine composite for treating acute/chronic bronchitis, as well as preparation method and quality control method thereof | JIANGSU JUMPCAN MEDICINES CO L | 2010-03-17 | — | — | CN | claimed |
| CN-1954868-A | Yinju Qingyan Preparation for treating disease by flaring-up of fire of deficiency type and preparation method and quality control method | BEIJING QIYUAN YIDE MEDICAL IN (CN) | 2007-05-02 | — | — | CN | claimed |
| CN-1311810-C | Process for preparing granular powder for treating blood stasis disease and quality control method | YITAI MEDICINE SCIENCE AND TEC (CN) | 2007-04-25 | — | — | CN | claimed |
| CN-1309372-C | Preparation of granular powder for treating hepatitis and quality control method | YITAI MEDICINE SCIENCE AND TEC (CN) | 2007-04-11 | — | — | CN | claimed |
| CN-1299759-C | Chinese medicine composition for treating dizziness and its preparing and quality control method | LUNAN PHARM CO LTD (CN) | 2007-02-14 | — | — | CN | claimed |
| CN-1663956-A | Process for extracting and separating aloe chromone from aloe leaves | UNIV BEIJING TECH & BUSINESS (CN) | 2005-09-07 | — | — | CN | claimed |
| CN-1616013-A | Chinese medicine composition for treating dizziness and its preparing and quality control method | LUNAN PHARM CO LTD (CN) | 2005-05-18 | — | — | CN | claimed |
| CN-1586611-A | Preparation of granular powder for treating hepatitis and quality control method | YITAI MEDICINE SCIENCE AND TEC (CN) | 2005-03-02 | — | — | CN | claimed |
| CN-1586612-A | Process for preparing granular powder for treating blood stasis disease and quality control method | YITAI MEDICINE SCIENCE AND TEC (CN) | 2005-03-02 | — | — | CN | claimed |
| US-5641485-A | WELL-TOLERATED ANTIFUNGALS | HOFFMANN-LA ROCHE INC. (US) | 1997-06-24 | — | — | US | claimed |