Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR8 | P51685 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL608528 | 0.78 | ALDH1A1 (0.76) | CCR8ALDH1A1KDM4EMAPTPKM | |
| Hydrochloric Acid SCHEMBL7438287 | 0.77 | ALDH1A1 (0.74) | CCR8ALDH1A1KDM4EMAPTPKM | |
| SCHEMBL8484919 | 0.76 | LTA4H (0.61) | CCR8ALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL3762996 | 0.75 | ACHE (0.49) | ALDH1A1KDM4E | |
| SCHEMBL3317577 | 0.74 | L3MBTL1 (0.71) | CCR8ALDH1A1KDM4EMAPT | |
| SCHEMBL1414283 | 0.74 | ALDH1A1 (0.67) | CCR8ALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL7158829 | 0.73 | CCR8 (0.76) | CCR8ALDH1A1KDM4EMAPT | |
| SCHEMBL1545229 | 0.71 | L3MBTL1 (0.74) | CCR8ALDH1A1KDM4EMAPT | |
| SCHEMBL14022760 | 0.71 | L3MBTL1 (0.74) | CCR8ALDH1A1KDM4EMAPT | |
| SCHEMBL8263564 | 0.71 | L3MBTL1 (0.74) | CCR8ALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751101-B1 | Substituted 5-aminomethyl-1H-pyrrole-2-carboxylic acid amides | GRUENENTHAL GMBH (DE) | 2012-11-14 | — | — | EP | claimed |
| US-7842812-B2 | Substituted 5-aminomethy1-1H-pyrrole-2-carboxylic acid amides | GRUENENTHAL GMBH (DE) | 2010-11-30 | — | — | US | claimed |
| US-20070135494-A1 | Substituted 5-aminomethyl-1H-pyrrole-2-carboxylic acid amides | GRUENENTHAL GMBH (DE) | 2007-06-14 | — | — | US | claimed |
| US-7842812-B2 | Substituted 5-aminomethy1-1H-pyrrole-2-carboxylic acid amides | GRUENENTHAL GMBH (DE) | 2010-11-30 | — | — | US | disclosed |
| US-20070135494-A1 | Substituted 5-aminomethyl-1H-pyrrole-2-carboxylic acid amides | GRUENENTHAL GMBH (DE) | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135494-A1 | Substituted 5-aminomethyl-1H-pyrrole-2-carboxylic acid amides | AVPR2, GPR119, AVPR1B | CCR8 1721/4885ALDH1A1 1027/4885NPC1 2758/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.