Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 5/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5187738 | 0.83 | ACHE (0.47) | ACHECHRM2CHRM3LMNAOPRM1 | |
| SCHEMBL3761870 | 0.82 | KDM4E (0.47) | CHRM2LMNATSHRKDM4EMEN1 | |
| SCHEMBL3764094 | 0.78 | HRH3 (0.48) | OPRM1HTTKDM4EMEN1ALDH1A1 | |
| SCHEMBL3762994 | 0.77 | NPC1 (0.51) | ACHELMNATSHRHTTKDM4E | |
| SCHEMBL3760934 | 0.75 | CCR8 (0.53) | KDM4EALDH1A1 | |
| SCHEMBL5187264 | 0.72 | BCHE (0.46) | ACHELMNAHTTKDM4EBCHE | |
| SCHEMBL3756217 | 0.70 | KDM4E (0.45) | LMNATSHRKDM4EMEN1ALDH1A1 | |
| SCHEMBL8732121 | 0.69 | CXCL8 (0.61) | TSHRHTTMEN1ALDH1A1KMT2A | |
| SCHEMBL3757509 | 0.69 | MEN1 (0.54) | HTTKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL156315 | 0.69 | ACHE (1.00) | ACHELMNABCHEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7842812-B2 | Substituted 5-aminomethy1-1H-pyrrole-2-carboxylic acid amides | GRUENENTHAL GMBH (DE) | 2010-11-30 | — | — | US | disclosed |
| US-20070135494-A1 | Substituted 5-aminomethyl-1H-pyrrole-2-carboxylic acid amides | GRUENENTHAL GMBH (DE) | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135494-A1 | Substituted 5-aminomethyl-1H-pyrrole-2-carboxylic acid amides | AVPR2, GPR119, AVPR1B | ACHE 873/4885CHRM2 491/4885CHRM3 1255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.