SCHEMBL376144

SCHEMBL376144

O=[C]Oc1cccc2c1Cc1ccccc1-2

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PNMT P11086 1/20 0.45
RAB9A P51151 4/20 0.43
NPC1 O15118 3/20 0.43
HTR7 P34969 1/20 0.40
HTR2B P41595 1/20 0.40
MAOA P21397 1/20 0.38
KDM4E B2RXH2 4/20 0.37
ALDH1A1 P00352 3/20 0.37
MAPT P10636 3/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
BCHE P06276 1/20 0.36
CES1 P23141 1/20 0.36
MAPK1 P28482 1/20 0.35
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
CA4 P22748 1/20 0.34
CA6 P23280 1/20 0.34
MAP3K9 P80192 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28832018 0.80 PNMT (0.52) PNMTRAB9ANPC1HTR7HTR2B
SCHEMBL1624465 0.79 PNMT (0.45) PNMTRAB9ANPC1HTR7HTR2B
SCHEMBL29090327 0.77 PNMT (0.49) PNMTRAB9ANPC1HTR7HTR2B
SCHEMBL15141606 0.77 PNMT (0.49) PNMTRAB9ANPC1HTR7HTR2B
SCHEMBL8854649 0.77 DRD2 (0.54) PNMTRAB9ANPC1KDM4EALDH1A1
SCHEMBL8840922 0.76 RAB9A (0.54) PNMTRAB9ANPC1HTR7HTR2B
SCHEMBL376145 0.76 PNMT (0.45) PNMTRAB9ANPC1HTR7HTR2B
SCHEMBL5496900 0.75 PNMT (0.47) PNMTRAB9ANPC1HTR7HTR2B
SCHEMBL20917777 0.75 RAB9A (0.49) PNMTRAB9ANPC1HTR7HTR2B
SCHEMBL30616301 0.75 RAB9A (0.49) PNMTRAB9ANPC1HTR7HTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 520 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4396163-A1 HERBICIDAL MALONAMIDES CONTAINING MONOCYCLIC HETEROAROMATIC RINGS BASF SE (DE) 2024-07-10 EP claimed
EP-4396173-A1 HERBICIDAL MALONAMIDES CONTAINING A CONDENSED RING SYSTEM BASF SE (DE) 2024-07-10 EP claimed
CN-117881667-A Herbicide malonamides containing a condensed ring system 巴斯夫欧洲公司 2024-04-12 CN claimed
CN-117881662-A Herbicide malonamide containing monocyclic heteroaromatic ring 巴斯夫欧洲公司 2024-04-12 CN claimed
WO-2023207710-A1 ANTIBODY-DRUG CONJUGATE, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF 四川科伦博泰生物医药股份有限公司 2023-11-02 WO claimed
CN-114656391-B Polyhydroxy pyrrolidine compound and preparation method and application thereof 中国科学院化学研究所 2023-10-24 CN claimed
CN-116731124-A Process for the preparation of cyclosporin and intermediates thereof 齐鲁制药有限公司 2023-09-12 CN claimed
WO-2023031200-A1 HERBICIDAL MALONAMIDES CONTAINING A CONDENSED RING SYSTEM BASF SE (DE) 2023-03-09 WO claimed
WO-2023031199-A1 HERBICIDAL MALONAMIDES CONTAINING MONOCYCLIC HETEROAROMATIC RINGS BASF SE (DE) 2023-03-09 WO claimed
CN-114656391-A Polyhydroxy pyrrolidine compound and preparation method and application thereof 中国科学院化学研究所 2022-06-24 CN claimed
WO-2001042242-A1 ANTIBACTERIAL HETEROBICYCLIC SUBSTITUTED PHENYL OXAZOLIDINONES ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2001-06-14 WO claimed
EP-0958283-A1 NEW COMPOUNDS WITH HEMOREGULATING EFFECT Nycomed Austria GmbH (AT) 1999-11-24 EP claimed
US-5861413-A BACTERICIDES, MICROBIOCIDES; VETERINARY MEDICINE BAYER AKTIENGESELLSCHAFT (DE) 1999-01-19 US claimed
WO-1998032738-A1 NEW COMPOUNDS WITH HEMOREGULATING EFFECT NYCOMED AUSTRIA GMBH (AT) 1998-07-30 WO claimed
EP-0785197-A2 2-oxo and 2-thio-1,2-dihydroquinolinyl-oxazolidinones BAYER AG (DE) 1997-07-23 EP claimed
US-5486476-A FOR USE IN THE PURIFICATION OF ANTIBODIES BOEHRINGER MANNHEIM GMBH (DE) 1996-01-23 US claimed
US-5449778-A Peptide intermediates WARNER-LAMBERT COMPANY (US) 1995-09-12 US claimed
EP-0637305-A1 NOVEL CYCLIC AMINO ACIDS AND DERIVATIVES THEREOF WARNER-LAMBERT COMPANY (US) 1995-02-08 EP claimed
US-5264577-A Cyclic amino acids and derivatives thereof WARNER-LAMBERT COMPANY (US) 1993-11-23 US claimed
WO-1993021176-A1 NOVEL CYCLIC AMINO ACIDS AND DERIVATIVES THEREOF WARNER-LAMBERT COMPANY (US) 1993-10-28 WO claimed