Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Orotic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.43 |
| ▸ | GRIN2A known ✓ | Q12879 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.91 |
| ▸ | LMNA | P02545 | 1/20 | 0.91 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Orotic Acid SCHEMBL29592552 | 0.98 | ALDH1A1 (0.95) | ALDH1A1LMNACYP2C19CYP1A2ALOX15 | |
| Orotic Acid SCHEMBL119625 | 0.98 | ALDH1A1 (0.95) | ALDH1A1LMNACYP2C19CYP1A2ALOX15 | |
| Orotic Acid SCHEMBL422602 | 0.98 | ALDH1A1 (0.95) | ALDH1A1LMNACYP2C19CYP1A2ALOX15 | |
| Orotic Acid SCHEMBL16916880 | 0.98 | ALDH1A1 (0.95) | ALDH1A1LMNACYP2C19CYP1A2ALOX15 | |
| Orotic Acid SCHEMBL28141346 | 0.96 | ALDH1A1 (0.91) | ALDH1A1LMNACYP2C19CYP1A2ALOX15 | |
| Orotic Acid SCHEMBL29394966 | 0.96 | ALDH1A1 (1.00) | ALDH1A1LMNACYP2C19CYP1A2ALOX15 | |
| Orotic Acid SCHEMBL431534 | 0.96 | ALDH1A1 (1.00) | ALDH1A1LMNACYP2C19CYP1A2ALOX15 | |
| Orotic Acid SCHEMBL20865 | 0.96 | ALDH1A1 (1.00) | ALDH1A1LMNACYP2C19CYP1A2ALOX15 | |
| Orotic Acid SCHEMBL23859825 | 0.93 | ALDH1A1 (0.95) | ALDH1A1LMNACYP2C19CYP1A2ALOX15 | |
| Orotic Acid SCHEMBL122311 | 0.93 | ALDH1A1 (0.95) | ALDH1A1LMNACYP2C19CYP1A2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408317-B1 | DIETARY SUPPLEMENT | GREENTEAM HOLDINGS LTD (GB) | 2017-10-04 | — | — | EP | claimed |
| EP-2996495-A1 | CALCIUM SUPPLEMENT | Calinnova Ltd (GB) | 2016-03-23 | — | — | EP | claimed |
| US-20150201650-A1 | DIETARY SUPPLEMENT | Greenteam Holdings Limited (GB) | 2015-07-23 | — | — | US | claimed |
| WO-2014177876-A1 | CALCIUM SUPPLEMENT | CALINNOVA LTD (GB) | 2014-11-06 | — | — | WO | claimed |
| US-20120121754-A1 | Dietary Supplement | CALLINOVA LTD (GB) | 2012-05-17 | — | — | US | claimed |
| EP-2408317-A1 | DIETARY SUPPLEMENT | Calinnova Ltd (GB) | 2012-01-25 | — | — | EP | claimed |
| WO-2010106351-A1 | DIETARY SUPPLEMENT | VETAFARM EUROPE LTD (GB) | 2010-09-23 | — | — | WO | claimed |
| EP-2408317-B1 | DIETARY SUPPLEMENT | GREENTEAM HOLDINGS LTD (GB) | 2017-10-04 | — | — | EP | disclosed |
| EP-2996495-A1 | CALCIUM SUPPLEMENT | Calinnova Ltd (GB) | 2016-03-23 | — | — | EP | disclosed |
| US-20150201650-A1 | DIETARY SUPPLEMENT | Greenteam Holdings Limited (GB) | 2015-07-23 | — | — | US | disclosed |
| WO-2014177876-A1 | CALCIUM SUPPLEMENT | CALINNOVA LTD (GB) | 2014-11-06 | — | — | WO | disclosed |
| US-20120121754-A1 | Dietary Supplement | CALLINOVA LTD (GB) | 2012-05-17 | — | — | US | disclosed |
| EP-2408317-A1 | DIETARY SUPPLEMENT | Calinnova Ltd (GB) | 2012-01-25 | — | — | EP | disclosed |
| WO-2010106351-A1 | DIETARY SUPPLEMENT | VETAFARM EUROPE LTD (GB) | 2010-09-23 | — | — | WO | disclosed |