SCHEMBL377724

SCHEMBL377724

Cc1cc(CO)cc(C)n1

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.43
MEN1 O00255 1/20 0.40
GAA P10253 1/20 0.40
MAPK1 P28482 1/20 0.40
KMT2A Q03164 1/20 0.40
HSD17B10 Q99714 2/20 0.39
KDM4E B2RXH2 1/20 0.38
ALDH1A1 P00352 1/20 0.38
LMNA P02545 1/20 0.37
HTT P42858 1/20 0.37
CYP2A6 P11509 1/20 0.36
POLB P06746 1/20 0.36
APOBEC3G Q9HC16 1/20 0.36
ABCG2 Q9UNQ0 1/20 0.36
ALPL P05186 1/20 0.34
ALPG P10696 1/20 0.34
PLAA Q9Y263 1/20 0.34
ABL1 P00519 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Formic Acid SCHEMBL31038510 0.89 ACHE (0.36) ACHEMEN1GAAMAPK1KMT2A
SCHEMBL11030024 0.85 ACHE (0.42) ACHEMEN1GAAMAPK1KMT2A
SCHEMBL31139293 0.85 ACHE (0.42) ACHEMEN1GAAMAPK1KMT2A
SCHEMBL31039215 0.84 ACHE (0.36) ACHEMEN1GAAMAPK1KMT2A
SCHEMBL501235 0.84 RECQL (0.45) ACHEMEN1GAAMAPK1KMT2A
SCHEMBL17656587 0.84 ACHE (0.36) ACHEMEN1GAAMAPK1KMT2A
SCHEMBL1828814 0.84 NOS2 (0.52) ACHEMEN1GAAMAPK1KMT2A
SCHEMBL568443 0.84 ACHE (0.36) ACHEMEN1GAAMAPK1KMT2A
SCHEMBL2747792 0.82 NOS3 (0.39) ACHEMEN1GAAMAPK1KMT2A
SCHEMBL1620417 0.80 ALDH1A1 (0.42) MEN1KMT2AKDM4EALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 153 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6620823-B2 Antiinflammatory agents; rheumatic disorders BRISTOL-MYERS SQUIBB PHARME COMPANY 2003-09-16 US claimed
US-12570666-B2 Furoindazole derivatives BAYER AKTIENGESELLSCHAFT (DE) 2026-03-10 US disclosed
EP-4126835-B1 INHIBITORS OF ANTIGEN PRESENTATION BY HLA-DR JANSSEN PHARMACEUTICA NV (BE) 2026-02-18 EP disclosed
US-12516038-B2 Inhibitors of antigen presentation by HLA-DR JANSSEN PHARMACEUTICA NV (BE) 2026-01-06 US disclosed
US-12421224-B2 Azetidinyl O-glycoprotein-2-acetamido-2-deoxy-3-D-glucopyranosidase inhibitors BIOGEN MA INC. (US) 2025-09-23 US disclosed
EP-4077334-B1 FUROINDAZOLE DERIVATIVES BAYER AG (DE) 2025-03-12 EP disclosed
EP-2408454-B1 NOVEL ANTI-INFLAMMATORY AGENTS RESVERLOGIX CORP (CA) 2024-07-24 EP disclosed
CN-115135656-B Furanoindazole derivatives 拜耳公司 2024-06-14 CN disclosed
US-11827620-B2 Compounds and uses thereof for detection of target molecules in a sample UNIVERSITE DE GENEVE (CH) 2023-11-28 US disclosed
US-11827620-B2 Compounds and uses thereof for detection of target molecules in a sample UNIVERSITE DE GENEVE (CH) 2023-11-28 US disclosed
WO-1993021214-A1 ALPHA-AMINOBORONIC ACID PEPTIDES AND THEIR USE AS ELASTASE INHIBITORS ZENECA LIMITED (GB) 1993-10-28 WO disclosed
US-5254558-A Substituted 1,3-diazines as leukocyte elastase inhibitors IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-10-19 US disclosed
US-5214152-A Insecticides, miticides TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1993-05-25 US disclosed
EP-0529680-A2 Intermediates, their production and their use for preparing alpha-unsaturated amines TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1993-03-03 EP disclosed
EP-0528633-A1 Pyrimidinyl acetamides as elastase inhibitors ZENECA LIMITED (GB) 1993-02-24 EP disclosed
US-5175301-A Insecticide, miticide, pesticide TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1992-12-29 US disclosed
EP-0509559-A2 Alpha-unsaturated amines, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1992-10-21 EP disclosed
EP-0509769-A2 Heterocyclic amides having HLE inhibiting activity ZENECA LIMITED (GB) 1992-10-21 EP disclosed
CN-1031079-A Alpha-unsaturated amines, process for their production and their use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1989-02-15 CN disclosed
EP-0302389-A2 Alpha-unsaturated amines, their production and use Takeda Chemical Industries, Ltd. (JP) 1989-02-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11827620-B2 Compounds and uses thereof for detection of target molecules in a sample POLRMT, SNRPE, POLI ACHE 4594/4885MEN1 2907/4885GAA 214/4885
US-12421224-B2 Azetidinyl O-glycoprotein-2-acetamido-2-deoxy-3-D-glucopyranosidase inhibitors UGGT1, MAN2A1, MAN2B2 ACHE 889/4885MEN1 3434/4885GAA 6/4885
US-12570666-B2 Furoindazole derivatives FURIN, CYP2F1, CYP3A7 ACHE 3994/4885MEN1 426/4885GAA 599/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.