Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | F2 | P00734 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3789880 | 0.94 | LMNA (0.45) | CNR2MAPTMEN1KMT2ALMNA | |
| SCHEMBL3781431 | 0.89 | EGFR (0.42) | MAPTMEN1KMT2ALMNAPTGS2 | |
| SCHEMBL3704729 | 0.88 | CNR2 (0.39) | CNR2SMN1; SMN2HTTCYP1A2 | |
| SCHEMBL3791356 | 0.87 | PTPN7 (0.40) | MAPTMEN1KMT2ALMNAPTGS2 | |
| SCHEMBL3785492 | 0.86 | CTSL (0.41) | MAPTMEN1KMT2ALMNAPTGS2 | |
| SCHEMBL13286377 | 0.81 | CNR2 (0.51) | CNR2MAPTMEN1KMT2ALMNA | |
| SCHEMBL3780588 | 0.81 | LMNA (0.42) | CNR2MAPTMEN1KMT2ALMNA | |
| SCHEMBL3788039 | 0.80 | MAPT (0.44) | CNR2MAPTMEN1KMT2ALMNA | |
| Ammonia Solution, Strong SCHEMBL3787729 | 0.79 | MAPT (0.46) | CNR2MAPTMEN1KMT2ALMNA | |
| SCHEMBL3786275 | 0.78 | USP10 (0.47) | MAPTMEN1KMT2ALMNAPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010083645-A1 | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF | SHANGHAI TARGETDRUG CO., LTD (CN) | 2010-07-29 | — | — | WO | disclosed |
| WO-2010083645-A1 | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF | SHANGHAI TARGETDRUG CO., LTD (CN) | 2010-07-29 | — | — | WO | disclosed |