Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 3/20 | 0.34 |
| ▸ | ACP1 | P24666 | 1/20 | 0.34 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | LATS1 | O95835 | 1/20 | 0.32 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 2/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3704729 | 0.83 | CNR2 (0.39) | SMN1; SMN2CNR2HTTNPC1RAB9A | |
| SCHEMBL3778147 | 0.81 | CNR2 (0.42) | LMNASMN1; SMN2MEN1KMT2ACNR2 | |
| SCHEMBL3789880 | 0.78 | LMNA (0.45) | LMNASMN1; SMN2MEN1KMT2ACNR2 | |
| SCHEMBL3782999 | 0.78 | KCNH3 (0.41) | LMNASMN1; SMN2MEN1KMT2AKCNH3 | |
| SCHEMBL3787051 | 0.71 | MEN1 (0.39) | LMNASMN1; SMN2MEN1KMT2AKCNH3 | |
| SCHEMBL3781431 | 0.70 | EGFR (0.42) | LMNAMEN1KMT2AMAPTHTT | |
| SCHEMBL3791356 | 0.68 | PTPN7 (0.40) | LMNAMEN1KMT2AMAPTHTT | |
| SCHEMBL3785492 | 0.68 | CTSL (0.41) | LMNAMEN1KMT2AMAPTHTT | |
| SCHEMBL25333149 | 0.67 | CNR2 (0.50) | CNR2NPC1RAB9A | |
| SCHEMBL20640073 | 0.67 | CNR2 (0.50) | CNR2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010083645-A1 | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF | SHANGHAI TARGETDRUG CO., LTD (CN) | 2010-07-29 | — | — | WO | disclosed |