Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | USP1 | O94782 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3791356 | 0.91 | PTPN7 (0.40) | EGFRERBB2MEN1KMT2AMAPT | |
| SCHEMBL3785492 | 0.90 | CTSL (0.41) | EGFRERBB2MEN1KMT2AMAPT | |
| SCHEMBL3778147 | 0.89 | CNR2 (0.42) | EGFRMEN1KMT2AMAPTLMNA | |
| SCHEMBL3789880 | 0.83 | LMNA (0.45) | EGFRMEN1KMT2AMAPTLMNA | |
| SCHEMBL3787119 | 0.81 | KCNH3 (0.39) | EGFRERBB2MEN1KMT2AMAPT | |
| SCHEMBL3704729 | 0.79 | CNR2 (0.39) | CYP1A2HTT | |
| SCHEMBL3786275 | 0.79 | USP10 (0.47) | EGFRERBB2MEN1KMT2AMAPT | |
| SCHEMBL3782046 | 0.76 | MPO (0.45) | MEN1KMT2AMAPTLMNAGAA | |
| SCHEMBL13286377 | 0.75 | CNR2 (0.51) | EGFRMEN1KMT2AMAPTLMNA | |
| SCHEMBL3783407 | 0.74 | CA1 (0.42) | MAPTGAAPTGS2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010083645-A1 | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF | SHANGHAI TARGETDRUG CO., LTD (CN) | 2010-07-29 | — | — | WO | claimed |
| WO-2010083645-A1 | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF | SHANGHAI TARGETDRUG CO., LTD (CN) | 2010-07-29 | — | — | WO | disclosed |