Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3778147 | 0.94 | CNR2 (0.42) | LMNAMEN1KMT2AMAPTCYP1A2 | |
| SCHEMBL3704729 | 0.85 | CNR2 (0.39) | CYP1A2SMN1; SMN2CNR2 | |
| SCHEMBL3781431 | 0.83 | EGFR (0.42) | LMNAMEN1KMT2AMAPTCYP1A2 | |
| SCHEMBL3791356 | 0.82 | PTPN7 (0.40) | LMNAMEN1KMT2AMAPTCYP1A2 | |
| SCHEMBL3785711 | 0.81 | KCNH3 (0.43) | LMNAMEN1KMT2AMAPTCYP1A2 | |
| SCHEMBL3785492 | 0.81 | CTSL (0.41) | LMNAMEN1KMT2AMAPTCYP1A2 | |
| SCHEMBL3780588 | 0.78 | LMNA (0.42) | LMNAMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL13286377 | 0.77 | CNR2 (0.51) | LMNAMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL3782046 | 0.75 | MPO (0.45) | LMNAMEN1KMT2AMAPTCYP1A2 | |
| SCHEMBL3788039 | 0.75 | MAPT (0.44) | LMNAMEN1KMT2AMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010083645-A1 | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF | SHANGHAI TARGETDRUG CO., LTD (CN) | 2010-07-29 | — | — | WO | claimed |
| WO-2010083645-A1 | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF | SHANGHAI TARGETDRUG CO., LTD (CN) | 2010-07-29 | — | — | WO | disclosed |
| WO-2010083645-A1 | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF | SHANGHAI TARGETDRUG CO., LTD (CN) | 2010-07-29 | — | — | WO | disclosed |