Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 15/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3778147 | 0.88 | CNR2 (0.42) | CNR2HTTSMN1; SMN2CYP1A2 | |
| SCHEMBL3789880 | 0.85 | LMNA (0.45) | CNR2SMN1; SMN2CYP1A2 | |
| SCHEMBL3780588 | 0.83 | LMNA (0.42) | CNR2NPC1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL3781431 | 0.79 | EGFR (0.42) | HTTCYP1A2 | |
| SCHEMBL3781206 | 0.78 | CNR2 (0.36) | CNR2IKBKBCHUKNPC1HTT | |
| SCHEMBL3791356 | 0.78 | PTPN7 (0.40) | HTTRAB9ACYP1A2 | |
| SCHEMBL3785492 | 0.77 | CTSL (0.41) | HTTCYP1A2 | |
| SCHEMBL3776179 | 0.72 | MPO (0.39) | CNR2IKBKBCHUKNPC1HTT | |
| SCHEMBL3779747 | 0.71 | MPO (0.38) | CNR2IKBKBCHUKNPC1HTT | |
| SCHEMBL3788039 | 0.70 | MAPT (0.44) | CNR2HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010083645-A1 | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF | SHANGHAI TARGETDRUG CO., LTD (CN) | 2010-07-29 | — | — | WO | claimed |
| WO-2010083645-A1 | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF | SHANGHAI TARGETDRUG CO., LTD (CN) | 2010-07-29 | — | — | WO | disclosed |